Literature DB >> 7275800

Effects of angiotensin II on the zona fasciculata of the rat adrenal cortex: an ultrastructural stereologic study.

G G Nussdorfer, C Robba, G Mazzochi, P Rebuffat.   

Abstract

The effects of a chronic administration of angiotensin II on the zona fasciculata of rats treated with dexamethasone and maintenance doses of ACTH were investigated by morphometric methods applied to electron microscopy. It was found that angiotensin induced a significant increase in the volume of cells, nuclei, mitochondrial and lipid compartments as well as in the surface area of smooth endoplasmic reticulum and mitochondrial cristae. Noticeable also were the hypertrophy of the Golgi apparatus and the increase in the number of acid phosphatase-positive dense bodies. These findings are interpreted as indicating that the renin-angiotensin system is involved in the stimulation of the growth and steroidogenic capacity of the rat zona fasciculata.

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Year:  1981        PMID： 7275800      PMCID： PMC1233369     

Source DB:  PubMed          Journal:  J Anat        ISSN： 0021-8782            Impact factor:   2.610


  18 in total

1.  Ultrastructure of the adrenal zona glomerulosa in children with renovascular hypertension.

Authors:  Y Hashida; E J Yunis
Journal:  Hum Pathol       Date:  1972-09       Impact factor: 3.466

2.  A stereologic study of the effects of ACTH and cyclic 3',5'-AMP on adrenocortical cells of intact and hypophysectomized rats.

Authors:  G G Nussdorfer; G Mazzocchi
Journal:  Lab Invest       Date:  1972-01       Impact factor: 5.662

3.  The ultrastructure of the aged rat zona fasciculata under various stressing procedures.

Authors:  D Szabó; C Dzsinich; I Okrös; E Stark
Journal:  Exp Gerontol       Date:  1970-12       Impact factor: 4.032

4.  Long-term trophic effect of ACTH on rat adrenocortical cells. An ultrastructural, morphometric and autoradiographic study.

Authors:  G Nussdorfer; G Mazzocchi; L Rebonato
Journal:  Z Zellforsch Mikrosk Anat       Date:  1971

5.  The localisation of acid phosphatase activity changes in lysosomes in the adrenal zona fasciculata of intact and hypophysectomized rats following ACTH administration.

Authors:  D Szabó; E Stark; B Varga
Journal:  Histochemie       Date:  1967

6.  Electron microscopic studies on the adrenal medulla and adrenal cortex of hypertensive rats. 2. Experimental hypertensive rats.

Authors:  T Maruyama
Journal:  Jpn Circ J       Date:  1972-04

Review 7.  Stereological principles for morphometry in electron microscopic cytology.

Authors:  E R Weibel
Journal:  Int Rev Cytol       Date:  1969

8.  Effects of corticosteroid-hormones on the smooth endoplasmic reticulum of rat adrenocortical cells.

Authors:  G G Nussdorfer
Journal:  Z Zellforsch Mikrosk Anat       Date:  1970

9.  Adrenal cholesterol: localization by electron-microscope autoradiography.

Authors:  H L Moses; W W Davis; A S Rosenthal; L D Garren
Journal:  Science       Date:  1969-03-14       Impact factor: 47.728

10.  Ultrastructural features of aldosterone production.

Authors:  E R Fisher; B Horvat
Journal:  Arch Pathol       Date:  1971-09
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  4 in total

1.  Covalent crosslinking of angiotensin II to its binding sites in rat adrenal membranes.

Authors:  S Paglin; J D Jamieson
Journal:  Proc Natl Acad Sci U S A       Date:  1982-06       Impact factor: 11.205

2.  In-vitro effects of angiotensin II on steroid production by hamster ovarian follicles and on ultrastructure of the theca interna.

Authors:  P H Kitzman; R J Hutz
Journal:  Cell Tissue Res       Date:  1992-04       Impact factor: 5.249

3.  Morphometric investigations into the mechanism of the compensatory hypertrophy of the rat adrenal zona fasciculata after unilateral adrenalectomy.

Authors:  C Robba; G Mazzocchi; P Rebuffat; G Gottardo; P Vassanelli; G G Nussdorfer
Journal:  Cell Tissue Res       Date:  1983       Impact factor: 5.249

4.  Long term effects of the hypocholesterolaemic drug 4-aminopyrazolo-pyrimidine on the zona fasciculata of the rat adrenal cortex.

Authors:  G Mazzocchi; C Robba; V Meneghelli; G G Nussdorfer
Journal:  J Anat       Date:  1986-12       Impact factor: 2.610
  4 in total

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