Pseudorabies in a dog.

Pseudorabies was diagnosed in a 5-year-old female crossbred dog by histologic examination and virus isolation. The clinical signs were depression, salivation, head pressing, and emesis. There were no gross pathologic findings. The microscopic findings in the brain stem consisted of mononuclear cell infiltrates in the leptomeninges, subarachnoid space, and neuropil. In addition, there were mononuclear cell perivascular cuffs, focal areas of gliosis, neuronal degeneration, and acidophilic intranuclear inclusions in neurons and astrocytes. Other microscopic findings were edema of lungs and fatty change in the liver. The virus was isolated from the brain and tonsils and identified by fluorescent antibody technique. Pseudorabies virus was isolated from pigs on the farm.