Carcinogenic effect of 1:3 propane sultone.

Eighty animals were administered propane sultone in either single or multiple doses. The skin lesions at the site of injection were due to necrosis, ulceration, destruction of the underlying muscle and varying grades of fibrosis. In 13 rats pseudosarcomatous changes were seen, the duration of which varied from 21 to 25 weeks after the first injection. Systemic examination revealed neoplastic pulmonary lesions in 17 rats that had been injected with propane sultone 21 to 25 weeks previously. The malignancies varied from adenocarcinoma to anaplastic carcinoma. Malignancy of lungs is here reported for the first time.