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Literature DB >> 7274389

Placental and fetal contraindications of dexamethasone administration to pregnant rats.

Abstract

Dexamethasone (DEXA) given to pregnant rats for either the last 3 or 6 days of gestation lowered placental, fetal body and adrenal weights. Histologically, DEXA-treated placentas appeared smaller than controls and showed signs of necrosis and pyknosis. Treated animals that were permitted to carry their litters to term did not deliver naturally, and most of their fetuses were dead when excised 1 day postmaturely.

Entities: Chemical Disease Species

Mesh：

Substances：
Dexamethasone

Year: 1981 PMID： 7274389 DOI： 10.1007/BF01967964

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

23 in total

1. MORPHOLOGIC CHANGES IN THE DEVELOPING RAT PLACENTA FOLLOWING PREDNISOLONE ADMINISTRATION.

Authors: W R BLACKBURN; H S KAPLAN; D G MCKAY
Journal: Am J Obstet Gynecol Date: 1965-05-15 Impact factor: 8.661

2. Foetal growth retardation and mortality by chronic dexamethasone administration to pregnant rats.

Authors: H Parvez; G Ismahan; S Parvez
Journal: J Endocrinol Date: 1976-10 Impact factor: 4.286

3. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants.

Authors: G C Liggins; R N Howie
Journal: Pediatrics Date: 1972-10 Impact factor: 7.124

4. [Antiproliferative and ncrosing action of adrenocortical and ovarian steroids on the invasive trophoblast of the placenta of the female rat].

Authors: L Badarau; L Gavrilita; G Ristescu; N Calinca
Journal: Rev Fr Gynecol Obstet Date: 1968-03

9. The effect of glucocorticoids on the maturation of premature lung membranes. Preventing the respiratory distress syndrome by glucocorticoids.

Authors: R E Thornfeldt; R W Franklin; N A Pickering; C R Thornfeldt; G Amell
Journal: Am J Obstet Gynecol Date: 1978-05-15 Impact factor: 8.661

10. Fetal rat adrenal growth and steroidogenesis in vitro after maternal dexamethasone treatment.

Authors: R Klepac; K Milković
Journal: Biol Neonate Date: 1979

1 in total

1. Placental toxicity in rats after administration of synthetic glucocorticoids. A morphological, histochemical and immunohistochemical investigation.

Authors: R Graf; R Gossrau; H G Frank
Journal: Anat Embryol (Berl) Date: 1989

1 in total

Placental and fetal contraindications of dexamethasone administration to pregnant rats.

1. MORPHOLOGIC CHANGES IN THE DEVELOPING RAT PLACENTA FOLLOWING PREDNISOLONE ADMINISTRATION.

2. Foetal growth retardation and mortality by chronic dexamethasone administration to pregnant rats.

3. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants.

4. [Antiproliferative and ncrosing action of adrenocortical and ovarian steroids on the invasive trophoblast of the placenta of the female rat].

5. Outcome for the foetus of mothers receiving prednisolone during pregnancy.

6. Sites of the negative feedback action of corticosteroids on the hypothalamo-hypophisial system of the rat fetus.

7. The effect of dexamethasone on pregnancy in the rabbit.

8. Premature parturition following dexamethasone administration to pregnant ewes.

9. The effect of glucocorticoids on the maturation of premature lung membranes. Preventing the respiratory distress syndrome by glucocorticoids.

10. Fetal rat adrenal growth and steroidogenesis in vitro after maternal dexamethasone treatment.

1. Placental toxicity in rats after administration of synthetic glucocorticoids. A morphological, histochemical and immunohistochemical investigation.