| Literature DB >> 7273598 |
Abstract
The influence of the prostaglandin (PG) synthesis-inhibiting, nonsteroidal anti-inflammatory drug (NSAID) diclofenac on lithium kinetics was studied in five normal women on a 150-mEq sodium diet. Diclofenac decreased lithium renal clearance by 23% (P - 0.002) and increased lithium plasma levels by 26% (P - 0.001). Renal PG synthesis was suppressed by 53% of control values. These data show a clinically important drug interaction, possibly on the basis of a PG-dependent mechanism, with the risk of lithium intoxication for patients treated with lithium salts and NSAIDs.Entities:
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Year: 1981 PMID： 7273598 DOI： 10.1038/clpt.1981.171
Source DB: PubMed Journal: Clin Pharmacol Ther ISSN： 0009-9236 Impact factor: 6.875