| Literature DB >> 7273027 |
J C Britell, C G Moertel, L K Kvols, M J O'Connell, J Rubin, A J Schutt.
Abstract
Oral 6-thioguanine (6-TG) is an S-phase antimetabolite with significant activity against acute leukemia. Preliminary reports of activity of iv 6-TG indicated significant activity against advanced colorectal cancer. We conducted a phase II study of iv 6-TG in 29 patients with advanced measurable colorectal cancer. Only one transient partial response occurred. Toxic effects included mild myelosuppression, nausea, vomiting, and minor ECG changes. We discourage further use of iv 6-TG in the dose and schedule we used to treat advanced colorectal cancer.Entities:
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Year: 1981 PMID： 7273027
Source DB: PubMed Journal: Cancer Treat Rep ISSN： 0361-5960