Literature DB >> 7272339

Comparison of the oxidation of glutamine, glucose, ketone bodies and fatty acids by human diploid fibroblasts.

C M Sumbilla, C L Zielke, W D Reed, P T Ozand, H R Zielke.   

Abstract

The contribution of glutamine, glucose, ketone bodies and fatty acids to the oxidative energy metabolism of human diploid fibroblasts ws studied. The rate of glutamine oxidation by fibroblasts was 98 nmol/h per mg cell protein compared to 2 nmol/h per mg cell protein or less for glucose, acetoacetate, D-3-hydroxybutyrate, octanoic acid and palmitic acid. Glucose inhibited glutamine oxidation by 85%, while the other substrates had no effect. Therefore, these cells meet their energy requirement almost solely by anaerobic glycolysis and glutamine oxidation.

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Year:  1981        PMID： 7272339     DOI： 10.1016/0304-4165(81)90242-7

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  8 in total

Review 1.  Hybridoma growth limitations: the roles of energy metabolism and ammonia production.

Authors:  M Newland; P F Greenfield; S Reid
Journal:  Cytotechnology       Date:  1990-05       Impact factor: 2.058

2.  Respective effects of glucose and glutamine on the glutamine synthetase activity of human skin fibroblasts.

Authors:  T Soni; C Wolfrom; S Guerroui; N Raynaud; J Poggi; N Moatti; M Gautier
Journal:  Mol Cell Biochem       Date:  1991-04-10       Impact factor: 3.396

Review 3.  Inborn error of amino acid synthesis: human glutamine synthetase deficiency.

Authors:  Johannes Häberle; Boris Görg; Annick Toutain; Frank Rutsch; Jean-François Benoist; Antoinette Gelot; Annie-Laure Suc; Hans Georg Koch; Freimut Schliess; Dieter Häussinger
Journal:  J Inherit Metab Dis       Date:  2006 Apr-Jun       Impact factor: 4.982

4.  Variation of amino acid concentrations in the medium of HU β-IFN and HU IL-2 producing cell lines.

Authors:  R Wagner; T Ryll; H Krafft; J Lehmann
Journal:  Cytotechnology       Date:  1988-02       Impact factor: 2.058

5.  Glutamine and glucose metabolism during thymocyte proliferation. Pathways of glutamine and glutamate metabolism.

Authors:  K Brand
Journal:  Biochem J       Date:  1985-06-01       Impact factor: 3.857

6.  Down-regulation of the hexose transport system: metabolic basis studied with a fibroblast mutant lacking phosphoglucose isomerase.

Authors:  D B Ullrey; A Franchi; J Pouyssegur; H M Kalckar
Journal:  Proc Natl Acad Sci U S A       Date:  1982-06       Impact factor: 11.205

7.  Further clues concerning the vectors essential to regulation of hexose transport, as studied in fibroblast cultures from a metabolic mutant.

Authors:  H M Kalckar; D B Ullrey
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

8.  Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors.

Authors:  C Peterson; J E Goldman
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205
  8 in total

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