[The inhibitory effect of dantrolene on the rise of serum-creatine-kinase activity after combined use of halothane and suxamethonium in man (author's transl)].

The effect of dantrolene (2 x 1 mg/kg) on the rise of serum CK activity after combined use of halothane and suxamethonium was the subject of a double-blind-study of 20 children. Dantrolene significantly inhibited the mean enzyme activity both post- and preoperatively. The incidence of suxamethonium-induced fasciculations was significantly reduced by dantrolene. Serum levels of dantrolene and its metabolites showed considerable interindividual variation; a relation between the levels and enzyme activity could not be detected. Comparing the enzyme-inhibiting effects of different methods dantrolene proved to be more effective than alcuronium preceding suxamethonium and "self-taming."

RCT Entities:   Population Interventions Outcomes