[The prognostic significance of stromal reaction and other histopathological parameters after Wertheim radical hysterectomy (author's transl)].

From 1969 to 1975 138 women were treated by Wertheim radical hysterectomy for invasive cancer of the cervix (28% stage IA, 54% stage IB, 9% stage IIA, and 9% stage IIB). 121 women were followed up for 5 years. The 5-year survival rate was 100% in stage IA cases, 88% in stage 1B and 75% in stage II patients. The following histopathological criteria and their prognostic significance were reviewed: stromal reaction, histological type, pattern of invasive spread, relationship to blood vessels and lymphatics, and regional lymph node metastasis. All patients with a strong stromal reaction were alive 5 year after the operation Undifferentiated carcinomas were seen much more frequently in the group of patients who died within 5 years. The pattern of invasive spread has no prognostic significance. All patients in whom the tumour had not spread to blood vessels and lymphatics survived more than 5 years. A strong stromal reaction seems to indicate a good host response and permits a more favourable prognosis to be made.