Literature DB >> 7268407

Hyperthermia-induced seizures in the rat pup: a model for febrile convulsions in children.

D Holtzman, K Obana, J Olson.   

Abstract

Seizures were produced in rat pups by ambient hyperthermia. Seizure threshold temperatures, measured rectally and intracerebrally, increased between 2 and 10 days of age. Electrocortical paroxysmal discharges were confirmed in hyperthermic 6- and 10-day-old pups. The increasing resistance to hyperthermic seizures with maturation and the electroencephalographic changes induced by hyperthermia are similar to those in young children.

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Mesh：

Year:  1981        PMID： 7268407     DOI： 10.1126/science.7268407

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  20 in total

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