Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Dopamine-induced ventilatory depression in the rat, mediated by carotid nerve afferents.

Literature DB >> 7266937

Dopamine-induced ventilatory depression in the rat, mediated by carotid nerve afferents.

Abstract

In pentobarbitone-anesthetized rats, i.v. injections of dopamine (DA) at (10-8)-(10-5 g/kg led to transient ventilatory depression, usually not associated with changes in systemic arterial pressure. DA-induced ventilatory depression consisted of decreases in tidal volume and respiratory frequency in 12 rats, and in bradypnea without changes in tidal volume in 5 rats. After bilateral section of the carotid nerves, ventilatory responses to DA were abolished or greatly diminished. It is concluded that DA inhibits carotid body chemosensory discharges in the rat. The possibility that chemosensory activity directly affects respiratory frequency is discussed.

Entities: Chemical Disease Species

Mesh：

Substances：
Dopamine

Year: 1981 PMID： 7266937 DOI： 10.1016/0304-3940(81)90354-2

Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046

Keyword Cloud
Cited

9 in total

1. Development of the arterial chemoreflex and turnover of carotid body catecholamines in the newborn rat.

Authors: T Hertzberg; S Hellström; H Lagercrantz; J M Pequignot
Journal: J Physiol Date: 1990-06 Impact factor: 5.182

2. Purinergic receptors in the carotid body as a new drug target for controlling hypertension.

Authors: Wioletta Pijacka; Davi J A Moraes; Laura E K Ratcliffe; Angus K Nightingale; Emma C Hart; Melina P da Silva; Benedito H Machado; Fiona D McBryde; Ana P Abdala; Anthony P Ford; Julian F R Paton
Journal: Nat Med Date: 2016-09-05 Impact factor: 53.440

8. Changes in carotid body amine levels and effects of dopamine on respiration in rats treated neonatally with capsaicin.

Authors: D S McQueen; A K Mir
Journal: Br J Pharmacol Date: 1984-12 Impact factor: 8.739

9. Functional and developmental studies of the peripheral arterial chemoreceptors in rat: effects of nicotine and possible relation to sudden infant death syndrome.

Authors: H Holgert; T Hökfelt; T Hertzberg; H Lagercrantz
Journal: Proc Natl Acad Sci U S A Date: 1995-08-01 Impact factor: 11.205

9 in total

Dopamine-induced ventilatory depression in the rat, mediated by carotid nerve afferents.

1. Development of the arterial chemoreflex and turnover of carotid body catecholamines in the newborn rat.

2. Purinergic receptors in the carotid body as a new drug target for controlling hypertension.

3. Ventilatory stimulation by dopamine-receptor antagonists in the mouse.

4. Effects of apomorphine and haloperidol in fetal lambs.

5. Maturation of carotid chemoreceptor sensitivity to hypoxia: in vitro studies in the newborn rat.

6. Analysis of cardiovascular responses evoked following changes in peripheral chemoreceptor activity in the rat.

7. Ventilatory response to hyperoxia in newborn rats born in hypoxia--possible relationship to carotid body dopamine.

8. Changes in carotid body amine levels and effects of dopamine on respiration in rats treated neonatally with capsaicin.

9. Functional and developmental studies of the peripheral arterial chemoreceptors in rat: effects of nicotine and possible relation to sudden infant death syndrome.