Literature DB >> 7266749

Clozapine inhibition of metenkephalin binding to synaptosome-enriched fractions of rat whole brain and hippocampus.

E Somoza, C Franco, M Laviña, J A Fuentes.   

Abstract

Clozapine has been found to inhibit the binding of [3H]met-enkephalin to synaptosome-enriched fractions prepared from rat whole brain and hippocampus in a Tris-buffered media without added ions. The IC50 value for hippocampus is 28.5 microM. The inhibition constant for whole brain (41.0 microM) was found to be slightly larger than the corresponding value for chlorpromazine, which was measured under similar experimental conditions.

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Year:  1981        PMID： 7266749     DOI： 10.1007/BF00963856

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  29 in total

1.  The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

Authors:  E G GRAY; V P WHITTAKER
Journal:  J Anat       Date:  1962-01       Impact factor: 2.610

Review 2.  Multiple receptors for dopamine.

Authors:  J W Kebabian; D B Calne
Journal:  Nature       Date:  1979-01-11       Impact factor: 49.962

3.  Diagnostic uses of the Hill (Logit and Nernst) plots.

Authors:  A Cornish-Bowden; D E Koshland
Journal:  J Mol Biol       Date:  1975-06-25       Impact factor: 5.469

4.  A peptide-containing fraction in the urine of schizophrenic patients which stimulates opiate receptors and inhibits dopamine uptake.

Authors:  K Hole; H Bergslien; H A Jørgensen; O G Berge; K L Reichelt; O E Trygstad
Journal:  Neuroscience       Date:  1979       Impact factor: 3.590

5.  Influence of neuroleptics on the binding of met-enkephalin, morphine and dihydromorphine to synaptosome-enriched fractions of rat brain.

Authors:  E Somoza
Journal:  Neuropharmacology       Date:  1978-08       Impact factor: 5.250

Review 6.  A systematic study of the pharmacological activities of dopamine antagonists.

Authors:  C J Niemegeers; P A Janssen
Journal:  Life Sci       Date:  1979-06-11       Impact factor: 5.037

7.  Morphine-like peptides, leucine enkephalin and methionine enkephalin: interactions with the opiate receptor.

Authors:  R Simantov; S H Snyder
Journal:  Mol Pharmacol       Date:  1976-11       Impact factor: 4.436

Review 8.  Opiate receptors and opioid peptides.

Authors:  S H Snyder; S R Childers
Journal:  Annu Rev Neurosci       Date:  1979       Impact factor: 12.449

9.  Radioreceptor assay of haloperidol tissue levels in the rat.

Authors:  B M Cohen; M Herschel; E Miller; H Mayberg; R J Baldessarini
Journal:  Neuropharmacology       Date:  1980-07       Impact factor: 5.250

10.  Clozapine concentrations in brain regions: relationship to dopamine metabolite increase.

Authors:  S Wilk; M Stanley
Journal:  Eur J Pharmacol       Date:  1978-09-15       Impact factor: 4.432
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