Literature DB >> 7265281

Immunopotentiating effect of vinca alkaloids on the antibody response to sheep red blood cells in the mouse.

J R Byrd, A M Isa.   

Abstract

Evidence is presented that the vinca alkaloids (vinblastine, vincristine, and vindesine) exert an immunopotentiating effect on the antibody response to sheep red blood cells (SRBC). The primary antibody response, measured by the rosette-forming cell (RFC) and hemagglutination (HA) assays, was enhanced by vincristine and vindesine treatments. Neither drug had any effect on the secondary antibody response. Vinblastine, while having no effect on the primary response, augmented the secondary antibody response to SRBC.

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Year:  1981        PMID： 7265281      PMCID： PMC2552687     

Source DB:  PubMed          Journal:  J Natl Med Assoc        ISSN： 0027-9684            Impact factor:   1.798


  5 in total

1.  Differential effect of vinblastine and colchicine on human active and total T rosettes.

Authors:  J Wybran; A Govaerts; H Fudenberg
Journal:  Int Arch Allergy Appl Immunol       Date:  1977

2.  Drugs which disrupt microtubules do not inhibit the initiation of lymphocyte activation.

Authors:  K Resch; D Bouillon; D Gemsa; R Averdunk
Journal:  Nature       Date:  1977-01-27       Impact factor: 49.962

3.  Human T lymphocyte receptors for sheep erythrocytes: conditions for binding including inhibition by cytochalasin B.

Authors:  J H Kersey; D J Hom; P Buttrick
Journal:  J Immunol       Date:  1974-02       Impact factor: 5.422

4.  Antitumor activity of deacetyl vinblastine amide sulfate (vindesine) in rodents and mitotic accumulation studies in culture.

Authors:  M J Sweeney; G B Boder; G J Cullinan; H W Culp; W D Daniels; R W Dyke; K Gerzon; R E McMahon; R L Nelson; G A Poore; G C Todd
Journal:  Cancer Res       Date:  1978-09       Impact factor: 12.701

5.  Effect of vinblastine on the early events in the humoral immune response of mice to SRBC.

Authors:  N Moav; L Steinberg; A Frensdorff
Journal:  Int Arch Allergy Appl Immunol       Date:  1976
  5 in total

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