| Literature DB >> 7265133 |
N B Mehta, C A Diuguid, F E Soroko.
Abstract
A selected group of alkoxy- and halogen-substituted 5-benzylidino- and 5-benzylhydantoins was prepared and screened for anticonvulsant activity as measured by the ability of the compound to prevent maximal electroshock and metrazol-induced threshold clonic seizures in rats. The structure-activity studies revealed 5-[3-(trifluoromethyl)benzyl]hydantoin (14) to be the most potent member of the series.Entities:
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Year: 1981 PMID： 7265133 DOI： 10.1021/jm00136a018
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446