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Literature DB >> 7265109

A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry.

Y C Martin.

Abstract

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Year: 1981 PMID： 7265109 DOI： 10.1021/jm00135a001

Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446

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20 in total

1. Nonlinear methods in the analysis of protein sequences: a case study in rubredoxins.

Authors: A Giuliani; R Benigni; P Sirabella; J P Zbilut; A Colosimo
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2. Prediction of membrane permeability to peptides from calculated dynamic molecular surface properties.

Authors: P Stenberg; K Luthman; P Artursson
Journal: Pharm Res Date: 1999-02 Impact factor: 4.200

Review 3. Neural networks as robust tools in drug lead discovery and development.

Authors: David A Winkler
Journal: Mol Biotechnol Date: 2004-06 Impact factor: 2.695

Review 4. Coexistence of passive and carrier-mediated processes in drug transport.

Authors: Kiyohiko Sugano; Manfred Kansy; Per Artursson; Alex Avdeef; Stefanie Bendels; Li Di; Gerhard F Ecker; Bernard Faller; Holger Fischer; Grégori Gerebtzoff; Hans Lennernaes; Frank Senner
Journal: Nat Rev Drug Discov Date: 2010-08 Impact factor: 84.694

5. Prediction of the intestinal absorption of endothelin receptor antagonists using three theoretical methods of increasing complexity.

Authors: P Stenberg; K Luthman; H Ellens; C P Lee; P L Smith; A Lago; J D Elliott; P Artursson
Journal: Pharm Res Date: 1999-10 Impact factor: 4.200

A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry.

1. Nonlinear methods in the analysis of protein sequences: a case study in rubredoxins.

2. Prediction of membrane permeability to peptides from calculated dynamic molecular surface properties.

Review 3. Neural networks as robust tools in drug lead discovery and development.

Review 4. Coexistence of passive and carrier-mediated processes in drug transport.

5. Prediction of the intestinal absorption of endothelin receptor antagonists using three theoretical methods of increasing complexity.

6. A study on the influence of molecular properties in the psychoactivity of cannabinoid compounds.

7. Energetic analysis of fragment docking and application to structure-based pharmacophore hypothesis generation.

Review 8. Modeling kinetics of subcellular disposition of chemicals.

Review 9. Carrier-mediated intestinal transport of drugs.

10. Computational approaches for modeling human intestinal absorption and permeability.