| Literature DB >> 7264657 |
P D Crane, W M Pardridge, L D Braun, A M Nyerges, W H Oldendorf.
Abstract
The relative cerebral cortical metabolism of glucose (GLU) and 2-deoxy-D-glucose (DG) was measured in vivo in control and insulin-treated hypoglycemic rats. The ratio of the utilization rate constants for the two hexoses, i.e., KDG/KGLU is defined as the Hexose Utilization Index (HUI). The HUI was found to be invariant in rats whose cerebral glucose content exceeded 1 mumol . g-1 wet weight (HUI = 0.48 +/- 0.07). Severe hypoglycemia (plasma glucose less than 2 mM) effected a shift in the HUI to 1.04 +/- 0.21. The results are consistent with a model in which the interpretation of the HUI is determined by the rate of transport into brain, or subsequent phosphorylation, as the rate-limiting step for hexose utilization.Entities:
Mesh：
Substances：
Year: 1981 PMID： 7264657 DOI： 10.1111/j.1471-4159.1981.tb00607.x
Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372