Literature DB >> 7264636

gamma-Aminobutyric acid concentration in cerebrospinal fluid in schizophrenia.

B W McCarthy, U R Gomes, A C Neethling, B C Shanley, J J Taljaard, L Potgieter, J T Roux.   

Abstract

gamma-Aminobutyric acid (GABA) concentration was determined in cerebrospinal fluid (CSF) of acute and chronic schizophrenic patients, in persons with psycho-organic or personality disorders, and in nonpsychiatric controls. The mean CSF GABA level in the chronic schizophrenic patients was found to be significantly higher than in any of the other groups. No other statistically significant differences were found. Statistical analysis revealed that the elevated CSF GABA concentration in the chronic schizophrenic patients was unlikely to be caused by medication. These results are interpreted as evidence for possible primary or secondary GABAergic overactivity in the brain in chronic schizophrenia.

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Year:  1981        PMID： 7264636     DOI： 10.1111/j.1471-4159.1981.tb00579.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  10 in total

Review 1.  Clinical relevance of measuring GABA concentrations in cerebrospinal fluid.

Authors:  P J Schechter; A Sjoerdsma
Journal:  Neurochem Res       Date:  1990-04       Impact factor: 3.996

2.  Elevated gamma-aminobutyric acid levels in chronic schizophrenia.

Authors:  Dost Ongür; Andrew P Prescot; Julie McCarthy; Bruce M Cohen; Perry F Renshaw
Journal:  Biol Psychiatry       Date:  2010-07-02       Impact factor: 13.382

Review 3.  Glutamate, GABA, and CNS disease: a review.

Authors:  J E Walker
Journal:  Neurochem Res       Date:  1983-04       Impact factor: 3.996

Review 4.  Alterations of central GABAergic activity in neurologic and psychiatric disorders: evaluation through measurements of GABA and GAD activity in cerebrospinal fluid.

Authors:  T A Hare
Journal:  Mol Cell Biochem       Date:  1981-09-25       Impact factor: 3.396

5.  In vivo magnetic resonance studies reveal neuroanatomical and neurochemical abnormalities in the serine racemase knockout mouse model of schizophrenia.

Authors:  Matthew D Puhl; Dionyssios Mintzopoulos; J Eric Jensen; Timothy E Gillis; Glenn T Konopaske; Marc J Kaufman; Joseph T Coyle
Journal:  Neurobiol Dis       Date:  2014-10-23       Impact factor: 5.996

6.  Gamma-aminobutyrate aminotransferase activity in brains of schizophrenic patients.

Authors:  F Sherif; L Eriksson; L Oreland
Journal:  J Neural Transm Gen Sect       Date:  1992

7.  Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis.

Authors:  D Rating; H Siemes; W Löscher
Journal:  J Neurol       Date:  1983       Impact factor: 4.849

Review 8.  Molecular substrates of schizophrenia: homeostatic signaling to connectivity.

Authors:  M A Landek-Salgado; T E Faust; A Sawa
Journal:  Mol Psychiatry       Date:  2015-09-22       Impact factor: 15.992

9.  CSF GABA is reduced in first-episode psychosis and associates to symptom severity.

Authors:  F Orhan; H Fatouros-Bergman; M Goiny; A Malmqvist; F Piehl; S Cervenka; K Collste; P Victorsson; C M Sellgren; L Flyckt; S Erhardt; G Engberg
Journal:  Mol Psychiatry       Date:  2017-03-14       Impact factor: 15.992

10.  GABA transporter-1 deficiency confers schizophrenia-like behavioral phenotypes.

Authors:  Zhe Yu; Qi Fang; Xian Xiao; Yi-Zhi Wang; You-Qing Cai; Hui Cao; Gang Hu; Zhong Chen; Jian Fei; Neng Gong; Tian-Le Xu
Journal:  PLoS One       Date:  2013-07-29       Impact factor: 3.240
  10 in total

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