Literature DB >> 7264609

Analysis of genome composition and reactogenicity of recombinants of cold-adapted and virulent virus strains.

Y Z Ghendon, A I Klimov, G I Alexandrova, F I Polezhaev.   

Abstract

Temperature-sensitive (ts) mutations occurring in three genes, 1, 2, and 7, and 1, 5 and 7 were found in two cold-adapted (ts) attenuated influenza virus strains A/Leningrad/9/37/46 (H0N1) and A/Leningrad/134/17/57 (H2N2) respectively. The recombinants, obtained by crossing these cold-adapted strains with virulent influenza virus strains, had different genome structures and inherited from one to six genes from the cold-adapted parents. Tests of reactogenicity of recombinants in volunteers showed all the recombinants to be non-reactogenic irrespective of the number of genes inherited from the cold-adapted parent.

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Year:  1981        PMID： 7264609     DOI： 10.1099/0022-1317-53-2-215

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  6 in total

1.  Molecular characteristics and biological properties (genetic markers) of candidate strains for preparation of live influenza virus vaccines.

Authors:  Y Z Ghendon
Journal:  Bull World Health Organ       Date:  1984       Impact factor: 9.408

2.  Influenza vaccination in older patients. Immunogenicity, epidemiology and available agents.

Authors:  H Glathe; W Lange
Journal:  Drugs Aging       Date:  1995-05       Impact factor: 3.923

3.  Recombinant cold-adapted attenuated influenza A vaccines for use in children: reactogenicity and antigenic activity of cold-adapted recombinants and analysis of isolates from the vaccinees.

Authors:  G I Alexandrova; F I Polezhaev; G N Budilovsky; L M Garmashova; N A Topuria; A Y Egorov; Y R Romejko-Gurko; T A Koval; K V Lisovskaya; A I Klimov
Journal:  Infect Immun       Date:  1984-06       Impact factor: 3.441

4.  Recombinant cold-adapted attenuated influenza A vaccines for use in children: molecular genetic analysis of the cold-adapted donor and recombinants.

Authors:  Y Z Ghendon; F I Polezhaev; K V Lisovskaya; T E Medvedeva; G I Alexandrova; A I Klimov
Journal:  Infect Immun       Date:  1984-06       Impact factor: 3.441

5.  Implementation of new approaches for generating conventional reassortants for live attenuated influenza vaccine based on Russian master donor viruses.

Authors:  Svetlana Shcherbik; Nicholas Pearce; Irina Kiseleva; Natalie Larionova; Larisa Rudenko; Xiyan Xu; David E Wentworth; Tatiana Bousse
Journal:  J Virol Methods       Date:  2015-10-28       Impact factor: 2.014

6.  Rapid strategy for screening by pyrosequencing of influenza virus reassortants--candidates for live attenuated vaccines.

Authors:  Svetlana V Shcherbik; Nicholas C Pearce; Marnie L Levine; Alexander I Klimov; Julie M Villanueva; Tatiana L Bousse
Journal:  PLoS One       Date:  2014-03-19       Impact factor: 3.240
  6 in total

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