The effect of duodeno-gastric reflux on serum gastrin levels in the dog.

Serum gastrin has been studied in dogs with and without surgically produced duodenal reflux. Fasting levels and the gastrin response to a standard meal have been assayed using a radioimmunoassay technique. Duodenal reflux caused no significant change in fasting serum gastrin immuno-reactivity but led to a markedly elevated and prolonged gastrin response to a standard meal.