Literature DB >> 7261249

Pharmacokinetics of methotrexate administered via the hepatic artery.

R J Ignoffo, S Oie, M A Friedman.   

Abstract

The pharmacokinetics of moderate doses of methotrexate administered via the hepatic artery were studied in ten patients with cancer metastatic to the liver. Intra-arterial methotrexate showed two-compartment characteristics with a clearance of 79 ml/min/m2 and an apparent volume of distribution of 21.2 l/m2 body surface area. The average half-life of the early phase was 1.9 h and the terminal half-life was 14.4 h. The data were not different from those observed in similar patients after IV administration of equivalent doses of methotrexate.

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Year:  1981        PMID： 7261249     DOI： 10.1007/BF00434387

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  6 in total

1.  Pharmacokinetics of methotrexate.

Authors:  D H Huffman; S H Wan; D L Azarnoff; B Hogstraten
Journal:  Clin Pharmacol Ther       Date:  1973 Jul-Aug       Impact factor: 6.875

2.  Intra-arterial infusion of anticancer drugs: theoretic aspects of drug delivery and review of responses.

Authors:  H S Chen; J F Gross
Journal:  Cancer Treat Rep       Date:  1980-01

3.  Pharmacokinetics of high-dose methotrexate with citrovorum factor rescue.

Authors:  W H Isacoff; P F Morrison; J Aroesty; K L Willis; J B Block; T L Lincoln
Journal:  Cancer Treat Rep       Date:  1977-12

4.  A clinical and pharmacological study of high-dose methotrexate with minimal leucovorin rescue.

Authors:  R G Stoller; H G Kaplan; F J Cummings; P Calabresi
Journal:  Cancer Res       Date:  1979-03       Impact factor: 12.701

5.  The use of regional chemotherapy in the management of malignant melanoma.

Authors:  E T Krementz; R D Carter; C M Sutherland; M Campbell
Journal:  World J Surg       Date:  1979-07-30       Impact factor: 3.352

6.  Competitive protein binding assay for methotrexate.

Authors:  C E Myers; M E Lippman; H M Elliot; B A Chabner
Journal:  Proc Natl Acad Sci U S A       Date:  1975-09       Impact factor: 11.205
  6 in total
  3 in total

1.  A pharmacokinetic study of adriamycin and 4'epi-adriamycin after simultaneous intra-arterial liver administration.

Authors:  S Eksborg; M Andersson; L Domellöf; U Lönroth
Journal:  Med Oncol Tumor Pharmacother       Date:  1986

2.  Intrahepatic and intravenous administration of adriamycin--a comparative pharmacokinetic study in patients with malignant liver tumours.

Authors:  S Eksborg; B J Cedermark; H S Strandler
Journal:  Med Oncol Tumor Pharmacother       Date:  1985

3.  Therapy of liver tumors metastatic from colorectal cancer with whole-liver radiation combined with 5-FU, adriamycin, and methotrexate.

Authors:  P A Volberding; M A Friedman; K J Resser; T L Phillips
Journal:  Cancer Chemother Pharmacol       Date:  1982       Impact factor: 3.333
  3 in total

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