Carcinomas of the cervix with intense stromal eosinophilia.

Stromal inflammatory reactions dominated by eosinophilic leukocytes have been reported in a small number of invasive cervical carcinomas. The clinicopathologic features of six patients whose cervical carcinomas were accompanied by an intense infiltrate of eosinophils were analyzed. Several patients also manifested an eosinophilia of peripheral blood and regional lymph nodes. The cervical carcinoma cells were regarded as the most likely cause of the tissue and blood eosinophilia since other etiologic factors were not identified. Eosinotactic and eosinopoietic substances probably either were produced directly by the carcinoma cells or resulted from immunologic interactions of inflammatory lymphoid cells and mast cells with antigens of the tumors. While stromal eosinophilia alone may not be of prognostic significance, eosinophilia of the peripheral blood may be an adverse sign in some patients with cervical carcinoma.