Single-drug chemotherapy with 5-FU and adriamycin in metastatic bladder cancer.

Either 5-fluorouracil (5-FU) or Adriamycin was used as single-drug treatment in 10 and 15 patients respectively with measurable metastatic bladder carcinoma. In the 5-FU group there were one complete and 2 partial remissions. Six partial remissions were observed in patients treated with Adriamycin. The duration of the remissions was usually short. Gastrointestinal and haematological side effects were more pronounced in the Adriamycin group. The results are discussed in relation to other reports on cytostatic treatment of bladder carcinoma, with emphasis on general problems concerning chemotherapy of this disease.