Literature DB >> 7260411

Correlation of chromosomal aberrations in a myeloma cell line with tumorigenicity in nude mice.

H H Kirchner, C Fonatsch, M Schaadt, M Günzel, K P Hellriegel, V Diehl.   

Abstract

A human myeloma cell line (L 363) exhibiting several markers of malignancy including a 14q + chromosome marker was not tumorigenic in nude mice. Long-term cultivation in vitro resulted in new subclones with slight, well-defined chromosomal differences to the original line. Certain subclones turned out to have a growth advantage in vitro and became tumorigenic after transplantation in nude mice. A strong correlation between changes in the chromosome I constellation resulting in the threefold dose of long arm-material and the increased proliferative potential in both experimental systems was found.

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Mesh：

Year:  1981        PMID： 7260411     DOI： 10.1007/BF00320467

Source DB:  PubMed          Journal:  Blut        ISSN： 0006-5242


  9 in total

1.  [Epstein-Barr virus (EBV) in lymphoid cells--a human tumor virus?].

Authors:  V Diehl
Journal:  Med Welt       Date:  1977-04-15

2.  Lymphoid cell lines: in vitro cell markers in correlation to tumorigenicity in nude mice.

Authors:  V Diehl; P Krause; K P Hellriegel; M Busche; I Schedel; E Laskewitz
Journal:  Haematol Blood Transfus       Date:  1977

3.  Long-term cultivation of plasma cell leukemia cells and autologous lymphoblasts (LCL) in vitro: a comparative study.

Authors:  V Diehl; M Schaadt; H Kirchner; K P Hellriegel; F Gudat; C Fonatsch; E Laskewitz; R Guggenheim
Journal:  Blut       Date:  1978-06-20

4.  New technique for distinguishing between human chromosomes.

Authors:  A T Sumner; H J Evans; R A Buckland
Journal:  Nat New Biol       Date:  1971-07-07

5.  Duplication of part of chromosome no. 1 in myeloproliferative diseases.

Authors:  G Gahrton; K Friberg; L Zech; J Lindsten
Journal:  Lancet       Date:  1978-01-14       Impact factor: 79.321

6.  Abnormalities of chromosome No. 1 in haematological malignancies.

Authors: 
Journal:  Lancet       Date:  1978-03-11       Impact factor: 79.321

7.  A possible correlation between the degree of karyotype aberrations and the rate of sister chromatid exchanges in lymphoma lines.

Authors:  C Fonatsch; M Schaadt; H Kirchner; V Diehl
Journal:  Int J Cancer       Date:  1980-12-15       Impact factor: 7.396

8.  Abnormalities of chromosome No. 1: significance in malignant transformation.

Authors:  J D Rowley
Journal:  Virchows Arch B Cell Pathol       Date:  1978-11-17

9.  Growth of diploid, Epstein-Barr virus-carrying human lymphoblastoid cell lines heterotransplanted into nude mice under immunologically privileged conditions.

Authors:  B Giovanella; K Nilsson; L Zech; O Yim; G Klein; J S Stehlin
Journal:  Int J Cancer       Date:  1979-07-15       Impact factor: 7.396
  9 in total
  2 in total

1.  Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma.

Authors:  Y Shou; M L Martelli; A Gabrea; Y Qi; L A Brents; A Roschke; G Dewald; I R Kirsch; P L Bergsagel; W M Kuehl
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-04       Impact factor: 11.205

2.  Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.

Authors:  Gijs van Haaften; Gillian L Dalgliesh; Helen Davies; Lina Chen; Graham Bignell; Chris Greenman; Sarah Edkins; Claire Hardy; Sarah O'Meara; Jon Teague; Adam Butler; Jonathan Hinton; Calli Latimer; Jenny Andrews; Syd Barthorpe; Dave Beare; Gemma Buck; Peter J Campbell; Jennifer Cole; Simon Forbes; Mingming Jia; David Jones; Chai Yin Kok; Catherine Leroy; Meng-Lay Lin; David J McBride; Mark Maddison; Simon Maquire; Kirsten McLay; Andrew Menzies; Tatiana Mironenko; Lee Mulderrig; Laura Mudie; Erin Pleasance; Rebecca Shepherd; Raffaella Smith; Lucy Stebbings; Philip Stephens; Gurpreet Tang; Patrick S Tarpey; Rachel Turner; Kelly Turrell; Jennifer Varian; Sofie West; Sara Widaa; Paul Wray; V Peter Collins; Koichi Ichimura; Simon Law; John Wong; Siu Tsan Yuen; Suet Yi Leung; Giovanni Tonon; Ronald A DePinho; Yu-Tzu Tai; Kenneth C Anderson; Richard J Kahnoski; Aaron Massie; Sok Kean Khoo; Bin Tean Teh; Michael R Stratton; P Andrew Futreal
Journal:  Nat Genet       Date:  2009-03-29       Impact factor: 38.330
  2 in total

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