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Literature DB >> 7260305

Incomplete inactivation of sodium currents in nonperfused squid axon.

Abstract

Perfused squid axons in which K-conductance is blocked show, under voltage clamp, incomplete inactivation of the sodium conductance. The presence of this phenomenon in nonperfused axons was found by comparing membrane current records before and after tetrodotoxin addition to the bathing solution. Sodium currents in nonperfused axons are comparable in behavior at positive potentials to those seen in Cs-perfused axons.

Entities: Chemical

Mesh：

Substances：
Cesium
Sodium

Year: 1980 PMID： 7260305 PMCID： PMC1327243 DOI： 10.1016/S0006-3495(80)85021-1

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

10 in total

1. A quantitative description of membrane current and its application to conduction and excitation in nerve.

Authors: A L HODGKIN; A F HUXLEY
Journal: J Physiol Date: 1952-08 Impact factor: 5.182

2. The dual effect of membrane potential on sodium conductance in the giant axon of Loligo.

Authors: A L HODGKIN; A F HUXLEY
Journal: J Physiol Date: 1952-04 Impact factor: 5.182

3. Inactivation of the sodium channel. II. Gating current experiments.

Authors: C M Armstrong; F Bezanilla
Journal: J Gen Physiol Date: 1977-11 Impact factor: 4.086

4. Rate constants associated with changes in sodium conductance in axons perfused with sodium fluoride.

Authors: W K Chandler; H Meves
Journal: J Physiol Date: 1970-12 Impact factor: 5.182

5. Sodium and potassium currents in squid axons perfused with fluoride solutions.

Authors: W K Chandler; H Meves
Journal: J Physiol Date: 1970-12 Impact factor: 5.182

6. Kinetic analysis of pancuronium interaction with sodium channels in squid axon membranes.

Authors: J Z Yeh; T Narahashi
Journal: J Gen Physiol Date: 1977-03 Impact factor: 4.086

7. Voltage clamp studies on the effect of internal cesium ion on sodium and potassium currents in the squid giant axon.

Authors: W J Adelman; J P Senft
Journal: J Gen Physiol Date: 1966-11 Impact factor: 4.086

8. Inactivation of the sodium channel. I. Sodium current experiments.

Authors: F Bezanilla; C M Armstrong
Journal: J Gen Physiol Date: 1977-11 Impact factor: 4.086

9. Dynamics of aminopyridine block of potassium channels in squid axon membrane.

Authors: J Z Yeh; G S Oxford; C H Wu; T Narahashi
Journal: J Gen Physiol Date: 1976-11 Impact factor: 4.086

10. Negative conductance caused by entry of sodium and cesium ions into the potassium channels of squid axons.

Authors: F Bezanilla; C M Armstrong
Journal: J Gen Physiol Date: 1972-11 Impact factor: 4.086

10 in total

14 in total

1. Spontaneous opening at zero membrane potential of sodium channels from eel electroplax reconstituted into lipid vesicles.

Authors: D S Duch; S R Levinson
Journal: J Membr Biol Date: 1987 Impact factor: 1.843

2. Noninactivating, tetrodotoxin-sensitive Na+ conductance in rat optic nerve axons.

Authors: P K Stys; H Sontheimer; B R Ransom; S G Waxman
Journal: Proc Natl Acad Sci U S A Date: 1993-08-01 Impact factor: 11.205

3. Gating of the squid sodium channel at positive potentials: II. Single channels reveal two open states.

Authors: A M Correa; F Bezanilla
Journal: Biophys J Date: 1994-06 Impact factor: 4.033

4. Sodium channel inactivation in the crayfish giant axon. Must channels open before inactivating?

Authors: B P Bean
Journal: Biophys J Date: 1981-09 Impact factor: 4.033

5. Relationship between membrane excitability and single channel open-close kinetics.

Authors: J R Clay; L J DeFelice
Journal: Biophys J Date: 1983-05 Impact factor: 4.033

6. Reconstituted voltage-sensitive sodium channels from eel electroplax: activation of permeability by quaternary lidocaine, N-bromoacetamide, and N-bromosuccinimide.

Authors: E C Cooper; W S Agnew
Journal: J Membr Biol Date: 1989-11 Impact factor: 1.843