Literature DB >> 7260289

An investigation of the effect of radioactive labeling of DNA on excision repair in UV-irradiated human fibroblasts.

U K Ehmann, E C Friedberg.   

Abstract

Previous studies on the kinetics of thymine dimer excision and unscheduled DNA synthesis in UV-irradiated human fibroblasts showed a significant discrepancy in these two parameters (Ehmann et al., 1978. Biophys. J. 22: 249). In the present study we have investigated the effect of the level of the radioactive isotope used for labeling cells on the kinetics of a parameter that directly measures thymine dimer excision. We find no significant differences in the kinetics of this parameter in cells lightly or heavily labeled with radioactive thymidine.

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Year:  1980        PMID： 7260289      PMCID： PMC1328785          DOI： 10.1016/S0006-3495(80)85058-2

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


  15 in total

1.  Symptoms of X-ray damage to radiosensitive mouse leukemic cells: asynchronous populations.

Authors:  U K Ehmann; H Nagasawa; D F Petersen; J T Lett
Journal:  Radiat Res       Date:  1974-12       Impact factor: 2.841

2.  Perturbations in cell cycle progression from radioactive DNA precursors.

Authors:  U K Ehmann; J R Williams; W A Nagle; J A Brown; J A Belli; J T Lett
Journal:  Nature       Date:  1975-12-18       Impact factor: 49.962

3.  Micrococcus luteus correndonucleases. I. resolution and purification of two endonucleases specific for DNA containing pyrimidine dimers.

Authors:  S Riazuddin; L Grossman
Journal:  J Biol Chem       Date:  1977-09-25       Impact factor: 5.157

4.  Endonuclease from Micrococcus luteus which has activity toward ultraviolet-irradiated deoxyribonucleic acid: purification and properties.

Authors:  W L Carrier; R B Setlow
Journal:  J Bacteriol       Date:  1970-04       Impact factor: 3.490

5.  Use of UV endonuclease from Micrococcus luteus to monitor the progress of DNA repair in UV-irradiated human cells.

Authors:  M C Paterson; P H Lohman; M L Sluyter
Journal:  Mutat Res       Date:  1973-08       Impact factor: 2.433

6.  Review and evaluation of molecular weight calculations from the sedimentation profiles of irradiated DNA.

Authors:  U K Ehmann; J T Lett
Journal:  Radiat Res       Date:  1973-04       Impact factor: 2.841

7.  Cell growth and division. IV. Determination of volume growth rate and division probability.

Authors:  E C Anderson; G I Bell; D F Petersen; R A Tobey
Journal:  Biophys J       Date:  1969-02       Impact factor: 4.033

8.  Synchronization of mouse L-P59 cells by centrifugal elutriation separation.

Authors:  M L Meistrich; R E Meyn; B Barlogie
Journal:  Exp Cell Res       Date:  1977-03-01       Impact factor: 3.905

9.  G2+M arrest of cultured mammalian cells after incorporation of tritium-labeled nucleosides.

Authors:  R Marz; J M Zylka; P G Plagemann; J Erbe; R Howard; J R Sheppard
Journal:  J Cell Physiol       Date:  1977-01       Impact factor: 6.384

10.  On the size of the DNA in the mammalian chromosome. Structural subunits.

Authors:  J T Lett; E S Klucis; C Sun
Journal:  Biophys J       Date:  1970-03       Impact factor: 4.033
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