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Literature DB >> 7259308

Evaluation of the toxic risk of DDT in the rat: during accumulation.

S Mitjavila, G Carrera, R A Boigegrain, R Derache.

Abstract

An investigation was undertaken on the accumulation of DDT and its metabolites in the rat. Rats received 14.5 mg DDT/kg b.w. every day for 52 days. Growth, food intake, body composition, and the activities of various enzymes were little affected. However, the level of total lipids fell 30% and the weight of the liver rose 20% due to cellular hypertrophy induced by the DDT. The quantity of DDT and its metabolites found in the carcass was 24 mg/rat i.e. three times that found in rats dead after a single dose of 200 mg/kg. Liver and brain contained 130 micrograms/rat and 10 micrograms/rat, respectively i.e. five times lower than those found in the rats which died from an acute dose of DDT. In the carcass, p,p' DDT accumulates more than p,p' DDE or p,p' DDD; the latter is preponderant in the liver.

Entities: Chemical Disease Species

Mesh：

Substances：
DDT

Year: 1981 PMID： 7259308 DOI： 10.1007/bf01055442

Source DB: PubMed Journal: Arch Environ Contam Toxicol ISSN： 0090-4341 Impact factor: 2.804

31 in total

1. Insecticide content of diet and body fat of Alaskan natives.

Authors: W F DURHAM; J F ARMSTRONG; W M UPHOLT; C HELLER
Journal: Science Date: 1961-12-08 Impact factor: 47.728

2. Storage and excretion of DDT in starved rats.

Authors: W E DALE; T B GAINES; W J HAYES
Journal: Toxicol Appl Pharmacol Date: 1962-01 Impact factor: 4.219

3. Storage of DDT and DDE in people with different degrees of exposure to DDT.

Authors: W J HAYES; G E QUINBY; K C WALKER; J W ELLIOTT; W M UPHOLT
Journal: AMA Arch Ind Health Date: 1958-11

4. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

Authors: K BURTON
Journal: Biochem J Date: 1956-02 Impact factor: 3.857

5. The effect of diet and 1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane (DDT) on microsomal hydroxylating enzymes and on sensitivity of rats to carbon tetrachloride poisoning.

Authors: A E McLean; E K McLean
Journal: Biochem J Date: 1966-08 Impact factor: 3.857

6. Changes in activity of rat brush border enzymes incubated with a homologous series of aliphatic alcohols.

Authors: S Mitjavila; C Lacombe; G Carrera
Journal: Biochem Pharmacol Date: 1976-03-15 Impact factor: 5.858

7. Relation of pesticide concentrations in fat to pathological changes in tissues.

Authors: W S Hoffman; H Adler; W I Fishbein; F C Bauer
Journal: Arch Environ Health Date: 1967-12

Review 8. The debate on DDT.

Authors: W B Deichmann
Journal: Arch Toxikol Date: 1972

Evaluation of the toxic risk of DDT in the rat: during accumulation.

1. Insecticide content of diet and body fat of Alaskan natives.

2. Storage and excretion of DDT in starved rats.

3. Storage of DDT and DDE in people with different degrees of exposure to DDT.

4. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

5. The effect of diet and 1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane (DDT) on microsomal hydroxylating enzymes and on sensitivity of rats to carbon tetrachloride poisoning.

6. Changes in activity of rat brush border enzymes incubated with a homologous series of aliphatic alcohols.

7. Relation of pesticide concentrations in fat to pathological changes in tissues.

Review 8. The debate on DDT.

9. Serum enzyme patterns in acute poisoning with organochlorine insecticides.

10. The effect of age and long-term low-level DDT exposure on the response to enzyme induction in the rat.

1. Chronic toxicity studies of crude organic chemical pollutants, illustrated by studies with Aroclor 1254.

2. Evaluation of the toxic risk of accumulated DDT in the rat: during fat mobilization.