Literature DB >> 7259165

Novel metabolites from Penicillium crustosum, including penitrem E, a tremorgenic mycotoxin.

N Kyriakidis, E S Waight, J B Day, P G Mantle.   

Abstract

Two new indolic metabolites were isolated from Penicillium crustosum and separated from other penitrem mycotoxins by high-performance liquid chromatography. Penitrem D is a deoxy-penitrem A. Penitrem E is dechloro-penitrem A and was shown to be tremorgenic in mice, although it has only one-third of the activity of penitrem A. Roquefortine was also shown, for the first time, to be an important metabolic product of P. crustosum.

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Year:  1981        PMID： 7259165      PMCID： PMC243961          DOI： 10.1128/aem.42.1.61-62.1981

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  6 in total

1.  Penitrem A and Roquefortine Production by Penicillium commune.

Authors:  R E Wagener; N D Davis; U L Diener
Journal:  Appl Environ Microbiol       Date:  1980-04       Impact factor: 4.792

2.  Tremorgenic toxin from Penicillium cyclopium grown on food materials.

Authors:  B J Wilson; C H Wilson; A W Hayes
Journal:  Nature       Date:  1968-10-05       Impact factor: 49.962

3.  Tremorgenic toxins from penicillia. 3. Tremortin production by Penicillium species on various agricultural commodities.

Authors:  C T Hou; A Ciegler; C W Hesseltine
Journal:  Appl Microbiol       Date:  1971-06

Review 4.  Mycotoxins: occurrence, chemistry, biological activity.

Authors:  A Ciegler
Journal:  Lloydia       Date:  1975 Jan-Feb

5.  Mycotoxic tremorgens of Claviceps paspali and Penicillium cyclopium: a comparative study of effects on sheep and cattle in relation to natural staggers syndromes.

Authors:  P G Mantle; P H Mortimer; E P White
Journal:  Res Vet Sci       Date:  1978-01       Impact factor: 2.534

6.  Clinical studies on tremorgenic mycotoxicoses in sheep.

Authors:  R H Penny; B M O'Sullivan; P G Mantle; B I Shaw
Journal:  Vet Rec       Date:  1979-10-27       Impact factor: 2.695
  6 in total
  6 in total

Review 1.  Oxidative Cyclization in Natural Product Biosynthesis.

Authors:  Man-Cheng Tang; Yi Zou; Kenji Watanabe; Christopher T Walsh; Yi Tang
Journal:  Chem Rev       Date:  2016-12-12       Impact factor: 60.622

2.  Biosynthesis of penitrems and roquefortine by Penicillium crustosum.

Authors:  P G Mantle; K P Perera; N J Maishman; G R Mundy
Journal:  Appl Environ Microbiol       Date:  1983-05       Impact factor: 4.792

3.  Complex etiology and pathology of mycotoxic nephropathy in South African pigs.

Authors:  Stoycho D Stoev; Stefan Denev; Mike F Dutton; Patrick B Njobeh; Joseph S Mosonik; Paul A Steenkamp; Iordan Petkov
Journal:  Mycotoxin Res       Date:  2009-11-17       Impact factor: 3.833

4.  Bioguided discovery and pharmacophore modeling of the mycotoxic indole diterpene alkaloids penitrems as breast cancer proliferation, migration, and invasion inhibitors.

Authors:  Asmaa A Sallam; Wael E Houssen; Chris R Gissendanner; Khaled Y Orabi; Ahmed I Foudah; Khalid A El Sayed
Journal:  Medchemcomm       Date:  2013-10       Impact factor: 3.597

5.  A water-damaged home and health of occupants: a case study.

Authors:  Jack Dwayne Thrasher; Michael R Gray; Kaye H Kilburn; Donald P Dennis; Archie Yu
Journal:  J Environ Public Health       Date:  2011-12-15

6.  Rapid Metabolome and Bioactivity Profiling of Fungi Associated with the Leaf and Rhizosphere of the Baltic Seagrass Zostera marina.

Authors:  Lars-Erik Petersen; Michael Marner; Antje Labes; Deniz Tasdemir
Journal:  Mar Drugs       Date:  2019-07-19       Impact factor: 5.118
  6 in total

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