Literature DB >> 7258186

A simple method for testing two-locus models of inheritance.

D A Greenberg.   

Abstract

A graphic method for testing simple two-locus models of inheritance is developed. The model assumes two alleles at each locus where both loci exhibit dominant, both exhibit recessive, or one locus exhibits dominant and one locus exhibits recessive inheritance. Examples of applying the graphs using published data on three diseases are given.

Mesh：

Year:  1981        PMID： 7258186      PMCID： PMC1685079     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  14 in total

1.  The study of genetic variation in Nigeria. II. The genetics of polydactyly.

Authors:  A B Scott-Emuakpor; E D Madueke
Journal:  Hum Hered       Date:  1976       Impact factor: 0.444

2.  Heredity of idiopathic haemochromatosis: a study of 106 families.

Authors:  M Simon; J L Alexandre; M Bourel; B Le Marec; C Scordia
Journal:  Clin Genet       Date:  1977-05       Impact factor: 4.438

3.  Genetic basis of gluten-sentitive enteropathy.

Authors:  A S Peña; D L Mann; N E Hague; J A Heck; H A van Leeuwen; J J van Rood; W Strober
Journal:  Gastroenterology       Date:  1978-08       Impact factor: 22.682

4.  Polymorphism of apolipoprotein E. II. Genetics of hyperlipoproteinemia type III.

Authors:  G Utermann; K H Vogelberg; A Steinmetz; W Schoenborn; N Pruin; M Jaeschke; M Hees; H Canzler
Journal:  Clin Genet       Date:  1979-01       Impact factor: 4.438

Review 5.  Statistical modeling and analysis in human genetics.

Authors:  R C Elston; D C Rao
Journal:  Annu Rev Biophys Bioeng       Date:  1978

6.  Diabetes mellitus in twins.

Authors:  M S Gottlieb; H F Root
Journal:  Diabetes       Date:  1968-11       Impact factor: 9.461

7.  A two-locus model for the inheritance of a familial disease.

Authors:  A Merry; J H Roger; R N Curnow
Journal:  Ann Hum Genet       Date:  1979-07       Impact factor: 1.670

8.  A two locus model for juvenile diabetes.

Authors:  G Thomson
Journal:  Ann Hum Genet       Date:  1980-05       Impact factor: 1.670

9.  Hereditary hemochromatosis. Phenotypic expression of the disease.

Authors:  G E Cartwright; C Q Edwards; K Kravitz; M Skolnick; D B Amos; A Johnson; L Buskjaer
Journal:  N Engl J Med       Date:  1979-07-26       Impact factor: 91.245

10.  Genetic linkage between hereditary hemochromatosis and HLA.

Authors:  K Kravitz; M Skolnick; C Cannings; D Carmelli; B Baty; B Amos; A Johnson; N Mendell; C Edwards; G Cartwright
Journal:  Am J Hum Genet       Date:  1979-09       Impact factor: 11.025
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  9 in total

1.  Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases.

Authors:  P C Abreu; D A Greenberg; S E Hodge
Journal:  Am J Hum Genet       Date:  1999-09       Impact factor: 11.025

2.  Two-locus models of disease: comparison of likelihood and nonparametric linkage methods.

Authors:  L R Goldin; D E Weeks
Journal:  Am J Hum Genet       Date:  1993-10       Impact factor: 11.025

3.  Simulation studies of segregation analysis: application to two-locus models.

Authors:  D A Greenberg
Journal:  Am J Hum Genet       Date:  1984-01       Impact factor: 11.025

4.  Evidence for recessive and against dominant inheritance at the HLA-"linked" locus in coeliac disease.

Authors:  D A Greenberg; S E Hodge; J I Rotter
Journal:  Am J Hum Genet       Date:  1982-03       Impact factor: 11.025

5.  Statistical properties of maximum likelihood estimators for genetic parameters of HLA-linked diseases.

Authors:  W J Ewens; R S Spielman
Journal:  Am J Hum Genet       Date:  1985-11       Impact factor: 11.025

6.  The search for heterogeneity in insulin-dependent diabetes mellitus (IDDM): linkage studies, two-locus models, and genetic heterogeneity.

Authors:  S E Hodge; C E Anderson; K Neiswanger; R S Sparkes; D L Rimoin
Journal:  Am J Hum Genet       Date:  1983-11       Impact factor: 11.025

7.  LAMPLINK: detection of statistically significant SNP combinations from GWAS data.

Authors:  Aika Terada; Ryo Yamada; Koji Tsuda; Jun Sese
Journal:  Bioinformatics       Date:  2016-07-13       Impact factor: 6.937

8.  An empirical fuzzy multifactor dimensionality reduction method for detecting gene-gene interactions.

Authors:  Sangseob Leem; Taesung Park
Journal:  BMC Genomics       Date:  2017-03-14       Impact factor: 3.969

9.  Using linkage analysis to detect gene-gene interaction by stratifying family data on known disease, or disease-associated, alleles.

Authors:  Barbara Corso; David A Greenberg
Journal:  PLoS One       Date:  2014-04-01       Impact factor: 3.240
  9 in total

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