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Literature DB >> 7256265

Centrilobular injury following hypoxia in isolated, perfused rat liver.

Abstract

Hypoxia was produced in isolated, hemoglobin-free, perfused rat liver by reducing the flow rate of oxygen-carrying fluid entering the organ. The procedure caused anoxia in centrilobular regions. In these anoxic areas, structural derangements developed rapidly, characterized by bleb-like protrusions of hepatocyte plasma membrane through fenestrations in the sinusoidal endothelium. Periportal tissue remained normoxic and was completely spared. Cellular injury resulting from localized anoxia may play an important role in the pathogenesis of centrilobular liver disease.

Entities: Chemical Disease Species

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NAD
NADP

Year: 1981 PMID： 7256265 DOI： 10.1126/science.7256265

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

20 in total

1. Dietary supplementation of some antioxidants against hypoxia.

Authors: Sanaa Ahmed Ali; Hanan Farouk Aly; Lilla Mohammed Faddah; Zeenat F Zaidi
Journal: World J Gastroenterol Date: 2012-11-28 Impact factor: 5.742

2. Ultrastructural changes in hepatocytes, sinusoidal endothelial cells and macrophages in hypothermic preservation of the rat liver with University of Wisconsin solution.

Authors: Y Okouchi; K Sasaki; T Tamaki
Journal: Virchows Arch Date: 1994 Impact factor: 4.064

3. Ultrastruct pathology of phalloidin-intoxicated hepatocytes in the presence and absence of extracellular calcium.

Authors: M A Russo; A B Kane; J L Farber
Journal: Am J Pathol Date: 1982-11 Impact factor: 4.307

4. Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia.

Authors: Shubhra Chaudhuri; Sandra S McCullough; Leah Hennings; Lynda Letzig; Pippa M Simpson; Jack A Hinson; Laura P James
Journal: Toxicol Appl Pharmacol Date: 2011-02-24 Impact factor: 4.219

5. Hepatotoxic interaction of sulindac with lipopolysaccharide: role of the hemostatic system.

Authors: Wei Zou; Sachin S Devi; Erica Sparkenbaugh; Husam S Younis; Robert A Roth; Patricia E Ganey
Journal: Toxicol Sci Date: 2008-12-12 Impact factor: 4.849

6. Periportal and pericentral pyridine nucleotide fluorescence from the surface of the perfused liver: evaluation of the hypothesis that chronic treatment with ethanol produces pericentral hypoxia.

Authors: S Ji; J J Lemasters; V Christenson; R G Thurman
Journal: Proc Natl Acad Sci U S A Date: 1982-09 Impact factor: 11.205

Centrilobular injury following hypoxia in isolated, perfused rat liver.

1. Dietary supplementation of some antioxidants against hypoxia.

2. Ultrastructural changes in hepatocytes, sinusoidal endothelial cells and macrophages in hypothermic preservation of the rat liver with University of Wisconsin solution.

3. Ultrastruct pathology of phalloidin-intoxicated hepatocytes in the presence and absence of extracellular calcium.

4. Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia.

5. Hepatotoxic interaction of sulindac with lipopolysaccharide: role of the hemostatic system.

6. Periportal and pericentral pyridine nucleotide fluorescence from the surface of the perfused liver: evaluation of the hypothesis that chronic treatment with ethanol produces pericentral hypoxia.

Review 7. Bioconjugation of oligonucleotides for treating liver fibrosis.

Review 8. The effect of respiratory disorders on clinical pharmacokinetic variables.

Review 9. Strategies to increase the resectability of hepatocellular carcinoma.

Review 10. Factors in the pathophysiology of the liver ischemia-reperfusion injury.