Literature DB >> 7255769

Release of vasoactive intestinal polypeptide by electrical field stimulation of rabbit ileum.

T S Gaginella, T M O'Dorisio, K A Hubel.   

Abstract

The release of vasoactive intestinal polypeptide (VIP) induced by electrical field stimulation (EFS) of rabbit ileum was studied in vitro. EFS parallel to the muscularis propria caused a significant increase in VIP concentration in the buffer bathing the serosal surface of full-thickness ileum. This effect was blocked by 10(-7) M tetrodotoxin. When circular and longitudinal muscle was removed, the amount of measurable VIP in the tissue decreased to about one-half that of full-thickness ileum, and EFS no longer caused release of VIP into the serosal or mucosal buffers. Our data indicate that EFS of rabbit ileum causes release of VIP, presumably form VIP-containing nerves present in the tissue. These results support the idea that VIP may be a physiological neuroregulator of intestinal function.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 7255769     DOI： 10.1016/0167-0115(81)90010-0

Source DB:  PubMed          Journal:  Regul Pept        ISSN： 0167-0115


  10 in total

1.  Glycogenolytic effect of vasoactive intestinal peptide in the rat in vivo.

Authors:  V Sánchez; R Goberna; J R Calvo
Journal:  Experientia       Date:  1991-06-15

Review 2.  Enteric nervous system. I. Physiology and pathophysiology of the intestinal tract.

Authors:  O Lundgren; J Svanvik; L Jivegård
Journal:  Dig Dis Sci       Date:  1989-02       Impact factor: 3.199

3.  Antisecretory actions of a novel vasoactive intestinal polypeptide (VIP) antagonist in human and rat small intestine.

Authors:  Matthew R Banks; Michael J G Farthing; Patrick Robberecht; David E Burleigh
Journal:  Br J Pharmacol       Date:  2005-04       Impact factor: 8.739

Review 4.  Vasoactive intestinal peptide.

Authors:  S I Said
Journal:  J Endocrinol Invest       Date:  1986-04       Impact factor: 4.256

5.  Enteric neural modulation of slow-wave activity in cat colon.

Authors:  C Du; J L Conklin; G Hammer
Journal:  Dig Dis Sci       Date:  1991-06       Impact factor: 3.199

6.  The effects of neuropeptide Y and its fragments upon basal and electrically stimulated ion secretion in rat jejunum mucosa.

Authors:  H M Cox; A W Cuthbert
Journal:  Br J Pharmacol       Date:  1990-10       Impact factor: 8.739

7.  Neurokinin A increases short-circuit current across rat colonic mucosa: a role for vasoactive intestinal polypeptide.

Authors:  X Y Tien; L J Wallace; J F Kachur; S Won-Kim; T S Gaginella
Journal:  J Physiol       Date:  1991-06       Impact factor: 5.182

8.  Investigations of nerve populations influencing ion transport that can be stimulated electrically, by serotonin and by a nicotinic agonist.

Authors:  J R Keast; J B Furness; M Costa
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-11       Impact factor: 3.000

9.  Vasoactive intestinal polypeptide mediates cholecystokinin-induced relaxation of the sphincter of Oddi.

Authors:  J W Wiley; T M O'Dorisio; C Owyang
Journal:  J Clin Invest       Date:  1988-06       Impact factor: 14.808

10.  Glucagon-Like Peptide-2 and the Enteric Nervous System Are Components of Cell-Cell Communication Pathway Regulating Intestinal Na+/Glucose Co-transport.

Authors:  Andrew W Moran; Miran A Al-Rammahi; Daniel J Batchelor; David M Bravo; Soraya P Shirazi-Beechey
Journal:  Front Nutr       Date:  2018-10-26
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.