Literature DB >> 7255768

Arginine vasopressin and a vasopressin antagonist peptide: opposite effects on extinction of active avoidance in rats.

G F Koob, M Le Moal, O Gaffori, M Manning, W H Sawyer, J Rivier, F E Bloom.   

Abstract

Systemic injection or arginine vasopressin (AVP) (1 micrograms/rat) significantly prolonged extinction of a pole-jump, active avoidance response in rats; lateral ventricular injection of 1000-fold less AVP (1 ng/rat) produced similar results. A new AVP analogue, [1-deaminopenicillamine-2-(O-methyl)tyrosine]arginine vasopressin (dPTyr-(Me)AVP), is known to antagonize behavioral and vascular effects of exogenous AVP at molar ratios of 5 : 1. At a dose of 100 micrograms/rat (subcutaneously) dPTyr-(Me)AVP produces, by itself, a behavioral effect opposite to that of exogenous AVP, namely a facilitation of extinction. Injections of dPTyr-(Me)AVP into the lateral ventricle were ineffective except at a dose of 10 micrograms/rat. These results confirm previous reports of the effect of vasopressin on delaying extinction of avoidance behavior, but suggest a site of action distant from the lateral ventricle.

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Year:  1981        PMID： 7255768     DOI： 10.1016/0167-0115(81)90009-4

Source DB:  PubMed          Journal:  Regul Pept        ISSN： 0167-0115


  9 in total

1.  Comparative physiological features of the regulatory effect of vasopressin on higher nervous activity in an ascending series of mammals.

Authors:  T N Sollertinskaya
Journal:  Neurosci Behav Physiol       Date:  1997 Nov-Dec

2.  Regional distribution of putative vasopressin receptors in rat brain and pituitary by quantitative autoradiography.

Authors:  R E Brinton; K W Gee; J K Wamsley; T P Davis; H I Yamamura
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

3.  A comparison of the effects of vasopressin and oxytocin with amphetamine and chlordiazepoxide on passive avoidance behaviour in rats.

Authors:  A Sahgal; C Wright
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

4.  Characterization of a uterine-type oxytocin receptor in the rat hippocampus.

Authors:  M Mühlethaler; W H Sawyer; M M Manning; J J Dreifuss
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205

5.  Interactive effects of neurohypophyseal neuropeptides with receptor antagonists on passive avoidance behavior: mediation by a cerebral neurohypophyseal hormone receptor?

Authors:  D de Wied; J Elands; G Kovács
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-15       Impact factor: 11.205

6.  Acute prosocial effects of oxytocin and vasopressin when given alone or in combination with 3,4-methylenedioxymethamphetamine in rats: involvement of the V1A receptor.

Authors:  Linnet Ramos; Callum Hicks; Richard Kevin; Alex Caminer; Rajeshwar Narlawar; Michael Kassiou; Iain S McGregor
Journal:  Neuropsychopharmacology       Date:  2013-05-16       Impact factor: 7.853

7.  EEG effects of subcutaneous and intracerebroventricular injections of arginine vasopressin in the rat.

Authors:  C L Ehlers; T K Reed; M Wang; C J Lebrun; G F Koob
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

8.  Hypothalamic Vasopressinergic Projections Innervate Central Amygdala GABAergic Neurons: Implications for Anxiety and Stress Coping.

Authors:  Vito S Hernández; Oscar R Hernández; Miguel Perez de la Mora; María J Gómora; Kjell Fuxe; Lee E Eiden; Limei Zhang
Journal:  Front Neural Circuits       Date:  2016-11-18       Impact factor: 3.492

Review 9.  Navigating Monogamy: Nonapeptide Sensitivity in a Memory Neural Circuit May Shape Social Behavior and Mating Decisions.

Authors:  Alexander G Ophir
Journal:  Front Neurosci       Date:  2017-07-11       Impact factor: 4.677
  9 in total

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