Literature DB >> 7252982

Synthesis and anticonvulsant activity of N-(benzoylalkyl)imidazoles and N-(omega-phenyl-omega-hydroxyalkyl)imidazoles.

D Nardi, A Tajana, A Leonardi, R Pennini, F Portioli, M J Magistretti, A Subissi.   

Abstract

A novel series of N-(benzoylalkyl)imidazoles and N-(omega-phenyl-omega-hydroxyalkyl)imidazoles was synthesized and evaluated for anticonvulsant activity in mice against maximal electroshock induced seizures. Some of the compounds showed an activity comparable to or better than phenytoin and phenobarbital. The N-[beta-[4-(beta-phenylethyl)phenyl]-beta-hydroxyethyl]imidazole (38) was selected for further studies; preclinical toxicology and additional efficacy evaluations are in progress. Structure-activity relationships are discussed.

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Year:  1981        PMID： 7252982     DOI： 10.1021/jm00138a017

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  7 in total

1.  Effect of denzimol on carbamazepine and carbamazepine-10,11-epoxide concentrations in serum, liver, spleen and different brain regions of the rat: an inhibitory metabolic interaction.

Authors:  P N Patsalos; M S Alavijeh; W Brownhill; P T Lascelles
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-01       Impact factor: 3.000

2.  Synthesis of imidazol-2-yl amino acids by using cells from alkane-oxidizing bacteria.

Authors:  Annett Mikolasch; Elke Hammer; Frieder Schauer
Journal:  Appl Environ Microbiol       Date:  2003-03       Impact factor: 4.792

3.  Preliminary note on the effect of denzimol in partial epilepsy.

Authors:  E Benassi; L Cocito; M Maffini; G P Bo; C Loeb
Journal:  Ital J Neurol Sci       Date:  1988-08

4.  Investigation of the mechanism of enantioseparation of some drug compounds by considering the mobile phase in HPLC by molecular dynamics simulation.

Authors:  Hamideh Barfeii; Zahra Garkani-Nejad; Vahid Saheb
Journal:  J Mol Model       Date:  2019-09-03       Impact factor: 1.810

5.  Synthesis of some novel hydrazono acyclic nucleoside analogues.

Authors:  Mohammad N Soltani Rad; Ali Khalafi-Nezhad; Somayeh Behrouz
Journal:  Beilstein J Org Chem       Date:  2010-05-17       Impact factor: 2.883

6.  Anticonvulsant potential of certain new (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides.

Authors:  Mohamed I Attia; Mohamed N Aboul-Enein; Aida A El-Azzouny; Yousreya A Maklad; Hazem A Ghabbour
Journal:  ScientificWorldJournal       Date:  2014-01-12

Review 7.  Allosteric GABAA Receptor Modulators-A Review on the Most Recent Heterocyclic Chemotypes and Their Synthetic Accessibility.

Authors:  Blanca Angelica Vega Alanis; Maria Teresa Iorio; Luca L Silva; Konstantina Bampali; Margot Ernst; Michael Schnürch; Marko D Mihovilovic
Journal:  Molecules       Date:  2020-02-24       Impact factor: 4.927
  7 in total

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