| Literature DB >> 7251472 |
R Okamoto, M Tsuchiya, H Nomura, H Iguchi, K Kiyoshima, S Hori, T Inui, T Sawa, T Takeuchi, H Umezawa.
Abstract
The antibacterial activity of acyl derivatives of tylosin were examined in vitro and in vivo. The 4"-acyl group in the acylated tylosins enhanced the antibacterial activity and antimycoplasmal activity against some macrolide-resistant strains. The orally administered 3-acetyl-4" -isovaleryltylosin produced a higher blood level in mice and rabbits than tylosin and a good therapeutic effect on the infection of Staphylococcus aureus Smith in mice.Entities:
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Year: 1980 PMID： 7251472 DOI： 10.7164/antibiotics.33.1309
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649