Prediction of multiple-dose blood level curves of drugs administered four times daily at non-uniform dosing intervals.

This paper describes a program which can predict multiple-dose blood level of drugs administered four times daily at non-uniform dosing intervals. The program is applicable to any drug in an individual, provided that the drug follows one-compartment pharmacokinetics after oral administration, while the fraction of the oral dose absorbed, the volume of distribution, the absorption rate constant and the elimination rate constant of the drug in this individual are known.