Literature DB >> 725088

The identification of trihydroxyeicosatrienoic acids as products from the incubation of arachidonic acid with washed blood platelets.

R L Jones, P J Kerry, N L Poyser, I C Walker, N H Wilson.   

Abstract

Arachidonic acid is converted by washed platelets from man, horse and dog into a mixture of 8,9,12-trihydroxyeicosa-5,10,14-trienoic acid and 8,11,12-trihydroxyeicosa-5,9,14-trienoic acid (termed 8,9,12-THETA and 8,11,12-THETA respectively and THETA collectively). Gas chromatographic--mass spectrometric evidence of structure is discussed.

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Year:  1978        PMID： 725088     DOI： 10.1016/0090-6980(78)90188-0

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  6 in total

1.  Hepoxilin A3 induces changes in cytosolic calcium, intracellular pH and membrane potential in human neutrophils.

Authors:  S Dho; S Grinstein; E J Corey; W G Su; C R Pace-Asciak
Journal:  Biochem J       Date:  1990-02-15       Impact factor: 3.857

Review 2.  Hepoxilins: a review on their enzymatic formation, metabolism and chemical synthesis.

Authors:  C R Pace-Asciak; D Reynaud; P M Demin
Journal:  Lipids       Date:  1995-02       Impact factor: 1.880

Review 3.  The prostanoids in hemostasis and thrombosis: a review.

Authors:  J B Smith
Journal:  Am J Pathol       Date:  1980-06       Impact factor: 4.307

4.  Arachidonate metabolism via lipoxygenase and 12L-hydroperoxy-5,8,10,14-icosatetraenoic acid peroxidase sensitive to anti-inflammatory drugs.

Authors:  M I Siegel; R T McConnell; N A Porter; P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1980-01       Impact factor: 11.205

5.  Monohydroxylated fatty acid substrate specificity of human leukocyte 5-lipoxygenase and omega-hydroxylase.

Authors:  M Guichardant; M Lagarde
Journal:  Biochem J       Date:  1988-12-15       Impact factor: 3.857

6.  Effects of reduced glutathione on the 12-lipoxygenase pathways in rat platelets.

Authors:  W C Chang; J Nakao; H Orimo; S Murota
Journal:  Biochem J       Date:  1982-03-15       Impact factor: 3.857
  6 in total

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