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Literature DB >> 7250325

Changes in immune reactivity during growth of an adenovirus 12-induced transplantable tumour in CBA mice.

Abstract

Early suppression, followed by a period of enhancement and finally, suppression, was seen when the spleen cell response to T and B cell mitogens was monitored during growth of an adenovirus 12-induced tumour in CBA black mice. The macrophage content of the tumour changed with time and these fluctuations correlated with the ability of tumour tissue extracts to enhance the normal spleen cell response to mitogen.

Entities: Disease Species

Mesh：

Year: 1981 PMID： 7250325 DOI： 10.1007/bf01986164

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

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References

16 in total

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Authors: D E Schumm; D F Billmire; H P Morris
Journal: Eur J Cancer Date: 1976-09 Impact factor: 9.162

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Authors: S A Eccles; P Alexander
Journal: Nature Date: 1974-08-23 Impact factor: 49.962

3. Immune response to adenovirus 12-induced tumour antigens, as measured in vitro by the macrophage migration inhibition test.

Authors: R C Rees; C W Potter
Journal: Eur J Cancer Date: 1973-07 Impact factor: 9.162

10. Cell-mediated immune responses in vitro. I. Suppression of the generation of cytotoxic lymphocytes by concanavalin A and concanavalin A-activated spleen cells.

Authors: D L Peavy; C W Pierce
Journal: J Exp Med Date: 1974-08-01 Impact factor: 14.307

Changes in immune reactivity during growth of an adenovirus 12-induced transplantable tumour in CBA mice.

1. Inhibition of mitogen-induced lymphocyte blastogenesis by serum from tumor-bearing animals: changes with tumor growth.

2. Macrophage content of tumours in relation to metastatic spread and host immune reaction.

3. Immune response to adenovirus 12-induced tumour antigens, as measured in vitro by the macrophage migration inhibition test.

4. In vivo studies of cell-mediated and humoral immune responses to adenovirus 12-induced tumour cells.

5. Macrophages in syngeneic animal tumours.

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10. Cell-mediated immune responses in vitro. I. Suppression of the generation of cytotoxic lymphocytes by concanavalin A and concanavalin A-activated spleen cells.