Inhibitory action of bradykinin on release of the adrenergic transmitter in the isolated lapine kidney.

In the isolated lapine kidney perfused with tyrode solution and prelabeled with [3H] norepinephrine, bradykinin (10 ng/ml) decreased the overflow of tritium elicited by sympathetic nerve stimulation both in the presence and absence of indomethacin. These observations indicate that bradykinin acts at presynaptic sites reducing release of the adrenergic transmitter in the isolated lapine kidney.