Reflux nephropathy.

Reflux nephropathy is the term now used to describe the irregular segmental scarring and contraction of the kidney which may occur in association with persistent vesicoureteric reflux. The condition is recognized as an important cause of renal failure and hypertension in children and young adults. Current evidence suggests that bacterial infection plays a dominant role in the initiation of scar formation, but other factors may contribute to progressive renal damage. The possibility has also been raised that sterile reflux may be harmful to the kidney.