Evaluation of plasma polymerized hexamethylcyclotrisiloxane biomaterials towards adhesion of canine platelets and leucocytes.

Silicone coated Celgard-2400 and Silastic membranes were prepared by plasma polymerization of hexamethylcyclotrisiloxane. The adhesion of canine platelets and leucocytes was tested by passing whole blood from the anaesthetized mongrel dog in an ex-vivo shunt system. The silicone control Celgard and silicone coated Silastic membranes had fewer platelets and fewer leucocytes compared to those on the control Silastic membranes. Furthermore, these blood cells underwent fewer morphological changes on the silicone coated Celgard and Silastic compared to those on the control Silastic. From these observations the silicone coated biomaterials were judged to be better than the Silastic as far as the adhesion of platelets and leucocytes are concerned.