Literature DB >> 7248317

Purification and partial characterization of prostaglandin D2 11-keto reductase in rabbit liver.

P Y Wong.   

Abstract

The cytoplasmic NADPH-dependent prostaglandin D2 11-keto reductase from rabbit liver was purified by a series of chromatographic procedures including isoelectric focusing. The enzyme catalyzed the conversion of prostaglandin D2 to prostaglandin F2 alpha and had a pH optimum of 7.0-7.5, and an isoelectric point of 5.8. The molecular weight was estimated to be 66 000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Enzymic activity was time and concentration dependent and required NADPH as cofactor.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 7248317     DOI： 10.1016/0005-2744(81)90281-3

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  8 in total

1.  Cellular communication inside the liver. Binding, conversion and metabolic effect of prostaglandin D2 on parenchymal liver cells.

Authors:  J Kuiper; F J Zijlstra; J A Kamps; T J Van Berkel
Journal:  Biochem J       Date:  1989-08-15       Impact factor: 3.857

Review 2.  Metabolic interactions between eicosanoids in blood and vascular cells.

Authors:  M Lagarde; N Gualde; M Rigaud
Journal:  Biochem J       Date:  1989-01-15       Impact factor: 3.857

3.  Enzymatic formation of prostaglandin F2 alpha in human brain.

Authors:  H Hayashi; Y Fujii; K Watanabe; O Hayaishi
Journal:  Neurochem Res       Date:  1990-04       Impact factor: 3.996

4.  9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma.

Authors:  Y Kikawa; S Narumiya; M Fukushima; H Wakatsuka; O Hayaishi
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

5.  Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans.

Authors:  T E Liston; L J Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

6.  Evidence against the formation of 13,14-dihydro-15-keto-prostaglandin F2 alpha following inhalation of prostaglandin D2 in man.

Authors:  C C Hardy; S T Holgate; C Robinson
Journal:  Br J Pharmacol       Date:  1986-03       Impact factor: 8.739

7.  (5Z,13E)-(15S)-9 alpha,11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2): formation and metabolism by human lung and contractile effects on human bronchial smooth muscle.

Authors:  K Seibert; J R Sheller; L J Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

8.  Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase.

Authors:  K Watanabe; Y Iguchi; S Iguchi; Y Arai; O Hayaishi; L J Roberts
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.