Literature DB >> 7243625

A p-methylbenzhydrylamine resin for improved solid-phase synthesis of peptide amides.

G R Matsueda, J M Stewart.   

Abstract

A p-methylbenzhydrylamine-resin, alpha-(p-tolyl)-amino-aminomethyl-functionalized copoly(styrene-1%-dvinylbenzene), was prepared for the improved solid-phase synthesis of peptide alpha-carboxamides. Following a Friedel-Crafts acylation of polymer beads, the resulting ketone resin was reductively aminated via the Leuckart reaction. A comparison of the relative acid stability of the p-methylbenzhydrylamine-(MBHA)-, benzhydrylamine (BHA)- and alpha-phenyethylamine-resins indicated that the p-methylbenzhydrylamine-resin provided the best yields of the model peptide carboxamides.

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Year:  1981        PMID： 7243625     DOI： 10.1016/s0196-9781(81)80010-1

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  14 in total

1.  Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes.

Authors:  M W Pennington; C Beeton; C A Galea; B J Smith; V Chi; K P Monaghan; A Garcia; S Rangaraju; A Giuffrida; D Plank; G Crossley; D Nugent; I Khaytin; Y Lefievre; I Peshenko; C Dixon; S Chauhan; A Orzel; T Inoue; X Hu; R V Moore; R S Norton; K G Chandy
Journal:  Mol Pharmacol       Date:  2009-01-02       Impact factor: 4.436

2.  Comparative fibril formation of analogs corresponding to the (12-24) segment of the β-amyloid peptide.

Authors:  Luciana Malavolta; Clóvis R Nakaie
Journal:  Neurol Sci       Date:  2011-09-09       Impact factor: 3.307

3.  Pancreastatin and islet hormone release.

Authors:  S Efendić; K Tatemoto; V Mutt; C Quan; D Chang; C G Ostenson
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

4.  Immunohistochemical studies using immunized Guinea pig sera with features of anti-human thyroid, eye and skeletal antibody and Graves' sera.

Authors:  Ildikó Molnár; Zita Szombathy; Ilona Kovács; A József Szentmiklósi
Journal:  J Clin Immunol       Date:  2007-01-23       Impact factor: 8.317

5.  Creation and functional screening of a multi-use peptide library.

Authors:  C K Jayawickreme; G F Graminski; J M Quillan; M R Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-01       Impact factor: 11.205

6.  A single-bead decode strategy using electrospray ionization mass spectrometry and a new photolabile linker: 3-amino-3-(2-nitrophenyl)propionic acid.

Authors:  B B Brown; D S Wagner; H M Geysen
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Review 7.  Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases.

Authors:  Christine Beeton; Michael W Pennington; Raymond S Norton
Journal:  Inflamm Allergy Drug Targets       Date:  2011-10

8.  Molecular cloning, cDNA sequencing, and chemical synthesis of cecropin B from Hyalophora cecropia.

Authors:  P van Hofsten; I Faye; K Kockum; J Y Lee; K G Xanthopoulos; I A Boman; H G Boman; A Engström; D Andreu; R B Merrifield
Journal:  Proc Natl Acad Sci U S A       Date:  1985-04       Impact factor: 11.205

9.  Minimum requirements for inhibition of smooth-muscle myosin light-chain kinase by synthetic peptides.

Authors:  J T Hunt; D M Floyd; V G Lee; D K Little; S Moreland
Journal:  Biochem J       Date:  1989-01-01       Impact factor: 3.857

10.  Retro and retroenantio analogs of cecropin-melittin hybrids.

Authors:  R B Merrifield; P Juvvadi; D Andreu; J Ubach; A Boman; H G Boman
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-11       Impact factor: 11.205
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