Literature DB >> 7243420

Mitomycin C test for diagnostic differentiation of idiopathic aplastic anemia and Fanconi anemia.

J Cervenka, D Arthur, C Yasis.   

Abstract

A cytogenetic test was developed to enable the diagnostic differentiation between Fanconi anemia and the group of disorders classified as "idiopathic" aplastic anemia. The method is based on the effect of the bifunctional alkylating agent mitomycin C (MMC) on chromosomes of peripheral lymphocytes in culture 92 to 96 hours. At the highest concentration of 80 ng/ml of MMC, about a 50-fold increase of chromosomal breaks and a 200-fold increase of radial figures was observed in Fanconi anemia lymphocytes in comparison with the average values for aplastic anemia cells or cells of healthy control subjects. In addition, sister chromatoid exchange analysis of cells treated with MMC demonstrated a marked inhibition of mitotic activity of lymphocytes of patients with increased sensitivity to MMC. It is advocated that the MMC-stress test should be used in each case of pancytopenia, as part of the therapy planning. The cytoreduction regimens used prior to bone marrow transplantation may produce lethal complications in patients with high clastogenic response to MMC.

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Year:  1981        PMID： 7243420

Source DB:  PubMed          Journal:  Pediatrics        ISSN： 0031-4005            Impact factor:   7.124


  28 in total

1.  Malignancies and survival patterns in the National Cancer Institute inherited bone marrow failure syndromes cohort study.

Authors:  Blanche P Alter; Neelam Giri; Sharon A Savage; June A Peters; Jennifer T Loud; Lisa Leathwood; Ann G Carr; Mark H Greene; Philip S Rosenberg
Journal:  Br J Haematol       Date:  2010-04-30       Impact factor: 6.998

2.  A locus for Fanconi anemia on 16q determined by homozygosity mapping.

Authors:  M Gschwend; O Levran; L Kruglyak; K Ranade; P C Verlander; S Shen; S Faure; J Weissenbach; C Altay; E S Lander; A D Auerbach; D Botstein
Journal:  Am J Hum Genet       Date:  1996-08       Impact factor: 11.025

3.  DNA semi-conservative synthesis in normal and Fanconi anemia fibroblasts following treatment with 8-methoxypsoralen and near ultraviolet light or with X-rays.

Authors:  E Moustacchi; C Diatloff-Zito
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

4.  Failure of diepoxybutane to enhance sister chromatid exchange levels in Fanconi's anemia patients and heterozygotes.

Authors:  B Porfirio; B Dallapiccola; V Mokini; G Alimena; E Gandini
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

Review 5.  Clinical geneticists' views of VACTERL/VATER association.

Authors:  Benjamin D Solomon; Kelly A Bear; Virginia Kimonis; Annelies de Klein; Daryl A Scott; Charles Shaw-Smith; Dick Tibboel; Heiko Reutter; Philip F Giampietro
Journal:  Am J Med Genet A       Date:  2012-11-19       Impact factor: 2.802

6.  Erythrocyte adenosine deaminase: diagnostic value for Diamond-Blackfan anaemia.

Authors:  John H Fargo; Christian P Kratz; Neelam Giri; Sharon A Savage; Carolyn Wong; Karen Backer; Blanche P Alter; Bertil Glader
Journal:  Br J Haematol       Date:  2012-12-17       Impact factor: 6.998

7.  Differential sensitivity of Fanconi anaemia lymphocytes to the clastogenic action of cis-diamminedichloroplatinum (II) and trans-diamminedichloroplatinum (II).

Authors:  E H Poll; F Arwert; H Joenje; A H Wanamarta
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

8.  Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells.

Authors:  Michael D Milsom; Bernhard Schiedlmeier; Jeff Bailey; Mi-Ok Kim; Dandan Li; Michael Jansen; Abdullah Mahmood Ali; Michelle Kirby; Christopher Baum; Leslie J Fairbairn; David A Williams
Journal:  Blood       Date:  2009-03-06       Impact factor: 22.113

9.  Unusual response to bifunctional alkylating agents in a case of Fanconi anaemia.

Authors:  M L Kwee; E H Poll; J J van de Kamp; H de Koning; A W Eriksson; H Joenje
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

10.  The identification of fanconi anemia genotypes by clastogenic stress.

Authors:  M M Cohen; S J Simpson; G R Honig; H S Maurer; J W Nicklas; A O Martin
Journal:  Am J Hum Genet       Date:  1982-09       Impact factor: 11.025
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