Literature DB >> 7242694

Effects of anticonvulsants and methotrexate on calcium disposition.

M A Evans.   

Abstract

Administration of phenytoin for 5 days significantly reduced oral absorption and bone uptake of radiolabelled calcium in mice. Acute treatment with phenytoin had no effect on calcium disposition. Pretreatment (1--5 days) with phenobarbital also had no effect of calcium disposition. Methotrexate pretreatment for 5 days increased the bone uptake of radiolabelled calcium presumably by decreasing calcium renal clearance. It is concluded that phenytoin induced reduction in calcium metabolism is unrelated to a state of functional folate deficiency.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 7242694     DOI： 10.1007/bf00504231

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  19 in total

1.  Liquid scintillation counting of calcium-45 in biological material.

Authors:  M Blanusa
Journal:  Anal Biochem       Date:  1975-11       Impact factor: 3.365

2.  Inhibition of vitamin D-stimulated active transport of calcium of rat intestine by diphenylhydantoin-phenobarbital treatment.

Authors:  H C Harrison; H E Harrison
Journal:  Proc Soc Exp Biol Med       Date:  1976-11

3.  Diphenylhydantoin: direct inhibition of the vitamin D3-mediated calcium absorptive mechanism in organ-cultured duodenum.

Authors:  R A Corradino
Journal:  Biochem Pharmacol       Date:  1976-04-01       Impact factor: 5.858

Review 4.  Basic and clinical concepts related to vitamin D metabolism and action (first of two parts).

Authors:  M R Haussler; T A McCain
Journal:  N Engl J Med       Date:  1977-11-03       Impact factor: 91.245

5.  Vitamin D-dependency rickets in institutionalized, mentally retarded children on long term anticonvulsant therapy. II. The response to 25-hydroxycholecalciferol and to vitamin D2.

Authors:  N Maclaren; F Lifshitz
Journal:  Pediatr Res       Date:  1973-11       Impact factor: 3.756

6.  Mechanism of folate deficiency in patients receiving phenytoin.

Authors:  A V Hoffbrand; T F Necheles
Journal:  Lancet       Date:  1968-09-07       Impact factor: 79.321

7.  Megaloblastic anaemia in anticonvulsant therapy.

Authors:  M J Meynell
Journal:  Lancet       Date:  1966-02-26       Impact factor: 79.321

8.  Biologic effects of 1,25-dihydroxycholecalciferol (a highly active vitamin D metabolite) in acutely uremic rats.

Authors:  R G Wong; A W Norman; C R Reddy; J W Coburn
Journal:  J Clin Invest       Date:  1972-05       Impact factor: 14.808

9.  Vitamin D-dependent rickets in institutionalized, mentally retarded children receiving long-term anticonvulsant therapy. I. A survey of 288 patients.

Authors:  F Lifshitz; N K Maclaren
Journal:  J Pediatr       Date:  1973-10       Impact factor: 4.406

10.  Plasma 1,25-dihydroxyvitamin D levels in patients receiving anticonvulsant drugs.

Authors:  W Jubiz; M R Haussler; T A McCain; K G Tolman
Journal:  J Clin Endocrinol Metab       Date:  1977-04       Impact factor: 5.958
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.