Literature DB >> 7241512

Inhibition of bovine and rat liver dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(4-substituted-phenyl)-s-triazines.

C Hansch, S W Dietrich, J Y Fukunaga.   

Abstract

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Year:  1981        PMID： 7241512     DOI： 10.1021/jm00137a013

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  5 in total

Review 1.  Chemical space of Escherichia coli dihydrofolate reductase inhibitors: New approaches for discovering novel drugs for old bugs.

Authors:  Bharath Srinivasan; Sam Tonddast-Navaei; Ambrish Roy; Hongyi Zhou; Jeffrey Skolnick
Journal:  Med Res Rev       Date:  2018-09-07       Impact factor: 12.944

2.  In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.

Authors:  David Plouffe; Achim Brinker; Case McNamara; Kerstin Henson; Nobutaka Kato; Kelli Kuhen; Advait Nagle; Francisco Adrián; Jason T Matzen; Paul Anderson; Tae-Gyu Nam; Nathanael S Gray; Arnab Chatterjee; Jeff Janes; S Frank Yan; Richard Trager; Jeremy S Caldwell; Peter G Schultz; Yingyao Zhou; Elizabeth A Winzeler
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-25       Impact factor: 11.205

3.  Ligand binding studies, preliminary structure-activity relationship and detailed mechanistic characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine derivatives as inhibitors of Escherichia coli dihydrofolate reductase.

Authors:  Bharath Srinivasan; Sam Tonddast-Navaei; Jeffrey Skolnick
Journal:  Eur J Med Chem       Date:  2015-09-05       Impact factor: 6.514

4.  Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus.

Authors:  Michele Tonelli; Lieve Naesens; Sabrina Gazzarrini; Matteo Santucci; Elena Cichero; Bruno Tasso; Anna Moroni; Maria Paola Costi; Roberta Loddo
Journal:  Eur J Med Chem       Date:  2017-04-27       Impact factor: 6.514

5.  Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase.

Authors:  Giusy Tassone; Giacomo Landi; Pasquale Linciano; Valeria Francesconi; Michele Tonelli; Lorenzo Tagliazucchi; Maria Paola Costi; Stefano Mangani; Cecilia Pozzi
Journal:  Pharmaceuticals (Basel)       Date:  2021-06-30
  5 in total

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