Literature DB >> 723953

Degenerate perturbations of protein structure as the mechanism of anaesthetic action.

C D Richards, K Martin, S Gregory, C A Keightley, T R Hesketh, G A Smith, G B Warren, J C Metcalfe.   

Abstract

The interaction of the n-alkanols with lipid bilayers and excitable membranes shows that there is no simple correlation between conduction block and any of the perturbations of bilayer structure currently proposed as unitary mechanisms of local anaesthetic action. We propose instead that the n-alkanols act by direct interaction with target proteins to cause perturbations which depend directly on the precise structure of the alcohol.

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Year:  1978        PMID： 723953     DOI： 10.1038/276775a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  34 in total

1.  Effect of inhalation anesthetics on swimming activity of artemia salina.

Authors:  M Takasaki; T Tatara; Y Suezaki; K Shirahama; H Kamaya; I Ueda; T Totoki
Journal:  J Anesth       Date:  1991-07       Impact factor: 2.078

2.  Anesthetic inhibition of firefly luciferase, a protein model for general anesthesia, does not exhibit pressure reversal.

Authors:  G W Moss; W R Lieb; N P Franks
Journal:  Biophys J       Date:  1991-12       Impact factor: 4.033

3.  Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties.

Authors:  Karl F Herold; R Lea Sanford; William Lee; Olaf S Andersen; Hugh C Hemmings
Journal:  Proc Natl Acad Sci U S A       Date:  2017-03-06       Impact factor: 11.205

4.  Gap junctional coupling modulates secretion of exocrine pancreas.

Authors:  P Meda; R Bruzzone; M Chanson; D Bosco; L Orci
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

5.  Anaesthetic potencies of primary alkanols: implications for the molecular dimensions of the anaesthetic site.

Authors:  J K Alifimoff; L L Firestone; K W Miller
Journal:  Br J Pharmacol       Date:  1989-01       Impact factor: 8.739

6.  Effects of solvents and alcohols on the polar lipid composition of Clostridium butyricum under conditions of controlled lipid chain composition.

Authors:  D L MacDonald; H Goldfine
Journal:  Appl Environ Microbiol       Date:  1991-12       Impact factor: 4.792

7.  The effect of temperature on the nerve-blocking action of benzyl alcohol on the squid giant axon.

Authors:  A A Harper; A G Macdonald; K T Wann
Journal:  J Physiol       Date:  1983-05       Impact factor: 5.182

8.  Intrinsic differences in the perturbing ability of alkanols in bilayer: action of phospholipase A2 on the alkanol-modified phospholipid bilayer.

Authors:  G C Upreti; S Rainier; M K Jain
Journal:  J Membr Biol       Date:  1980-07-15       Impact factor: 1.843

9.  Glucagon-stimulated adenylate cyclase detects a selective perturbation of the inner half of the liver plasma-membrane bilayer achieved by the local anaesthetic prilocaine.

Authors:  M D Houslay; I Dipple; S Rawal; R D Sauerheber; J A Esgate; L M Gordon
Journal:  Biochem J       Date:  1980-07-15       Impact factor: 3.857

10.  General anesthetics can competitively interfere with sensitive membrane proteins.

Authors:  P W Tas; H G Kress; K Koschel
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205
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