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Literature DB >> 7238832

The influence of sodium 8-chlorotheophyllinate (S8CT) on immune processes.

Abstract

S8CT injected at the time of immunization significantly enhances specific IgM-production but has no effect on IgG-formation. Mitogen (PHA-P) induced macrophage migration inhibition of cells of S8CT pretreated animals is reduced. The same effect is observed, when normal cells are tested in the presence of S8CT in vitro. Blast transformation of B-lymphocytes but not of thymocytes is significantly stimulated by S8CT. Acid phosphatase activity is also stimulated in B-cells and - to a lesser degree - in cortisone-resistant T-lymphocytes whereas the activity of the total thymocyte population is reduced. No effect was seen on phagocytosis and intracellular bactericidal activity. A stimulatory effect of S8CT for B-cells is postulated.

Entities: Chemical

Mesh：

Substances：

Year: 1981 PMID： 7238832 DOI： 10.1007/bf01959898

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

22 in total

1. [The anion complex penicillinate-8-chlorotheophyllinate].

Authors: G GILLISSEN; W STORBECK
Journal: Arzneimittelforschung Date: 1960-09

2. Modulation of stimulated phospholipid metabolism in mast cells by pharmacologic agents that increase cyclic 3',5' adenosine monophosphate levels.

Authors: D A Kennerly; C J Secosan; C W Parker; T J Sullivan
Journal: J Immunol Date: 1979-10 Impact factor: 5.422

Review 3. The role of cyclic nucleotides in lymphocyte activation and function.

Authors: T B Strom; A P Lundin; C B Carpenter
Journal: Prog Clin Immunol Date: 1977

4. Activation of human B lymphocytes VII. the regulatory effect of cyclic adenosine monophosphate on human B cell activation.

Authors: P Katz; A S Fauci
Journal: J Allergy Clin Immunol Date: 1978-05 Impact factor: 10.793

The influence of sodium 8-chlorotheophyllinate (S8CT) on immune processes.

1. [The anion complex penicillinate-8-chlorotheophyllinate].

2. Modulation of stimulated phospholipid metabolism in mast cells by pharmacologic agents that increase cyclic 3',5' adenosine monophosphate levels.

Review 3. The role of cyclic nucleotides in lymphocyte activation and function.

4. Activation of human B lymphocytes VII. the regulatory effect of cyclic adenosine monophosphate on human B cell activation.

5. Induction and separation of antigen-dependent T helper and T suppressor cells in man.

6. Influence of cyclic AMP on early events of the immune induction.

7. Biphasic effect of cyclic AMP on an immune response.

8. Increased lysosomal acid phosphatase activity as an early event of phytohemagglutinin stimulation.

9. Effects of arachidonic acid and other unsaturated fatty acids on mitogenesis in human lymphocytes.

10. Plaque Formation in Agar by Single Antibody-Producing Cells.

1. Non-specific influence of antibiotics on the course of infectious processes.