| Literature DB >> 7238769 |
B M Altura, G Lum, P D Turlapaty, B T Altura.
Abstract
16-week-old Wistar, alloxan diabetic rats exhibited progressive elevations in levels of serum glucose, total triglycerides, cholesterol and creatinine over a period of 8 weeks; hyperglycemia preceded hyperlipidemia and hypercreatininemia and hypertriglyceridemia preceded hypercholesteremia. Age-matched control rats failed to develop any signs of hyperglycemia or hypercreatininemia, but did develop both hypercholesterolemia and hypertriglyceridemia at 24 weeks of age. This suggests that the progressive cardiovascular derangements (e.g., atherosclerosis, hypertension) noted in experimental diabetes mellitus and in the normal aging (and maturation) process may be brought about by distinctly different biochemical processes.Entities:
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Year: 1981 PMID： 7238769 DOI： 10.1007/bf01991622
Source DB: PubMed Journal: Experientia ISSN： 0014-4754