Cyclic erythropoiesis in W/Wv mice following a single small dose of 89Sr.

Young adult female W/Wv mice were given 0.5 microCi 89Sr/g intravenously, a dose which produces no anemia and only mild transient thrombocytopenia in normal mice. In the W/Wv animals platelet counts fell from 10(6) to 3 x 10(5)/mm3, and hematocrits from 39% to 25% in two weeks. In the following 2 weeks, platelet counts rose to 7 x 10(5), stabilizing at this level. Average hematocrit values were observed to oscillate from a nadir of 26% to a zenith of 42%, with a periodicity of about 16 days. In a repeat experiment we found the average hematocrit fluctuation from 28 to 40%, amplitude of reticulocyte fluctuation 6 to 31%, periodicity of cycle 16 days. Several animals have been observed through as many as six complete cycles. Further study of cyclical erythropoiesis in the W/Wv mouse following hematopoietic injury produced by 89Sr may shed light on the causes of cyclical hematopoiesis observed occasionally in man and other animals.