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Literature DB >> 723784

Growth of some attenuated influenza A viruses in hamsters.

Abstract

The replication of three attenuated influenza viruses in SPF hamsters inoculated by aerosol was investigated. Strains A2-Eng, A2-Victoria, ts-1-[E] A2-Victoria recombinant, and the RIT 4050 strain all multiplied to high titers in hamster lungs and induced both primary and secondary serological responses. Recombinant strain, A/AA/6/60-A2-Vic (CR22) multiplied to lower titers in hamsters. Differences were observed between the infectivity of different strains for hamsters, the wild-type viruses A2-Eng and A2-Vic being the most infective.

Entities: Disease Species

Mesh：

Substances：
Antibodies, Viral

Year: 1978 PMID： 723784 DOI： 10.1007/bf02121142

Source DB: PubMed Journal: Med Microbiol Immunol ISSN： 0300-8584 Impact factor: 3.402

5 in total

1. The hamster as an experimental animal for the study of influenza. II. The role of spleen cells in protection.

Authors: R Jennings; J P Phair; M D Denton; C W Potter
Journal: Med Microbiol Immunol Date: 1976-12-01 Impact factor: 3.402

2. Temperature-sensitive mutants of influenza virus. I. Behavior in tissue culture and in experimental animals.

Authors: J Mills; V Chanock; R M Chanock
Journal: J Infect Dis Date: 1971-02 Impact factor: 5.226

3. An evaluation of influenza A/Victoria/3/75-ts-1 [E] recombinant viruses for attenuation and immunogenicity in adult seronegative volunteers.

Authors: B R Murphy; L J Markoff; R M Chanock; R G Douglas; R F Betts; T R Cate; R B Couch
Journal: Dev Biol Stand Date: 1977 Jun 1-3

Growth of some attenuated influenza A viruses in hamsters.

1. The hamster as an experimental animal for the study of influenza. II. The role of spleen cells in protection.

2. Temperature-sensitive mutants of influenza virus. I. Behavior in tissue culture and in experimental animals.

3. An evaluation of influenza A/Victoria/3/75-ts-1 [E] recombinant viruses for attenuation and immunogenicity in adult seronegative volunteers.

4. The hamster as an experimental animal for the study of influenza. I. The role of antibody in protection.

5. Laboratory and clinical evaluation of new live influenza virus vaccines. Need for minimum requirements.

1. Syrian Hamster as an Animal Model for the Study of Human Influenza Virus Infection.

2. Studies with some influenza B viruses in cell cultures, hamsters and hamster tracheal organ cultures.

3. Growth of influenza A viruses in hamsters.

4. Growth of some attenuated influenza viruses in hamster tracheal organ cultures.

5. Animal Models for Influenza Virus Pathogenesis and Transmission.