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Literature DB >> 7236996

Theophylline inhibition of renal and cerebral nucleoside formation.

Abstract

1 Theophylline inhibits the enzymatic formation of purine nucleosides, among these adenosine (dephosphorylated adenosine 5'-monophosphate), in kidney and brain of the rat. 2 Some pharmacological effects of theophylline on regional blood flow and electrophysiological activity of the nervous system may be caused by inhibition of the endogenous formation of adenosine.

Entities: Chemical Species

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Year: 1981 PMID： 7236996 PMCID： PMC2071679 DOI： 10.1111/j.1476-5381.1981.tb10444.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

18 in total

1. Aminophylline increases cerebral metabolic rate and decreases anoxic survival in young mice.

Authors: J H Thurston; R E Hauhard; J A Dirgo
Journal: Science Date: 1978-08-18 Impact factor: 47.728

2. Effects of adenosine analogs on rat cerebral cortical neurons.

Authors: J W Phillis; J P Edstrom
Journal: Life Sci Date: 1976-10-01 Impact factor: 5.037

3. Antagonistic effects of theophylline and adenosine on adrenergic neuroeffector transmission in the rabbit kidney.

Authors: P Hedqvist; B B Fredholm; S Olundh
Journal: Circ Res Date: 1978-10 Impact factor: 17.367

Review 4. Bioassay and pharmacologic evaluation of the adenosine hypothesis.

Authors: F J Haddy
Journal: Adv Exp Med Biol Date: 1977 Impact factor: 2.622

5. The effect of adenosine and adenine nucleotides on the cyclic adenosine 3', 5'-phosphate content of guinea pig cerebral cortex slices.

Authors: A Sattin; T W Rall
Journal: Mol Pharmacol Date: 1970-01 Impact factor: 4.436

6. Tissue content of adenosine, inosine and hypoxanthine in the rat kidney after ischemia and postischemic recirculation.

Authors: H Osswald; H J Schmitz; R Kemper
Journal: Pflugers Arch Date: 1977-10-19 Impact factor: 3.657

10. Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.

Authors: R W BUTCHER; E W SUTHERLAND
Journal: J Biol Chem Date: 1962-04 Impact factor: 5.157

1 in total

Review 1. Theophylline poisoning. Pharmacological considerations and clinical management.

Authors: P Gaudreault; J Guay
Journal: Med Toxicol Date: 1986 May-Jun